Trends in HbA1c and other biochemical outcomes of individuals with newly diagnosed type 1 diabetes
| Autor: | A. O’Carroll-Lolait, J. Schofield, I. Doughty, Hood Thabit, Lalantha Leelarathna, Andrea Urwin |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Complications HbA1c Adolescent Statistical difference Blood Pressure 030209 endocrinology & metabolism Newly diagnosed 030204 cardiovascular system & hematology Body Mass Index Young Adult 03 medical and health sciences 0302 clinical medicine Age groups Internal medicine medicine Humans Cardiovascular risk factors Retrospective Studies Glycated Hemoglobin Type 1 diabetes business.industry Infant General Medicine medicine.disease Obesity Diabetes Mellitus Type 1 Blood pressure Female Original Article High incidence business Body mass index |
| Zdroj: | O’carroll-lolait, A, Urwin, A, Doughty, I, Schofield, J, Thabit, H & Leelarathna, L 2020, ' Trends in HbA1c and other biochemical outcomes of individuals with newly diagnosed type 1 diabetes ', Irish Journal of Medical Science . https://doi.org/10.1007/s11845-020-02434-w Irish Journal of Medical Science |
| ISSN: | 1863-4362 0021-1265 |
| DOI: | 10.1007/s11845-020-02434-w |
| Popis: | BackgroundThere is limited data on glycaemic control and cardiovascular risk factor management in newly diagnosed individuals with type 1 diabetes in the first 2 years.MethodsRetrospective, single centre study from the North West of England, newly diagnosed with type 1 diabetes between 2014 and 2018 (n= 58). HbA1c, blood pressure, lipids and body mass index (BMI) data were collected from electronic patient records from the time of diagnosis until the end of 2 years, stratified by age 16–24 years or ≥ 25 years at presentation.ResultsFor those aged 16–24 years (n= 31), median (IQR), HbA1c improved at 6 months from 83 (63–93) to 51.5 (46–75) mmol/mol (p= 0.001) and remained stable 6–24 months. For those ≥ 25 years (n= 27), HbA1c declined from 91 (70–107) to 65 (50–89) mmol/mol, (p< 0.01) at 6 months and declined further to 52 mmol/mol (44–70) at 24 months. At 24 months, 27.8% of all individuals had an HbA1c ≥ 69 mmol/mol. Approximately, a third met LDL (< 2 mmol/L) and total cholesterol (< 4 mmol/L) targets. A total of 58.6% of individuals were overweight/obese (BMI > 25 kg/m2) at 24 months compared to 45.8% at baseline. There were no significant blood pressure changes during the follow-up.ConclusionsIn both age groups, significant improvement of HbA1c occurred within the first 6 months of diagnosis with no statistical difference between the two groups at any of the time points up to 24 months. Despite significant improvements in HbA1c, majority had levels > 53 mmol/mol at 24 months. Alongside the high incidence of obesity and dyslipidaemia, our data support the need for further intensification of therapy from diagnosis of type 1 diabetes. |
| Databáze: | OpenAIRE |
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