Diffusion tensor imaging findings in children with sluggish cognitive tempo comorbid Attention Deficit Hyperactivity Disorder
| Autor: | Muharrem Burak Baytunca, Gül Ünsel-Bolat, Burcu Kardaş, Eyüp Sabri Ercan, Mehmet Cem Çallı, Sevim Berrin Inci Izmir, Melis Ipci, Onur Özyurt |
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| Přispěvatelé: | HKÜ, İktisadi, İdari ve Sosyal Bilimler Fakültesi, Psikoloji Bölümü, Işık Üniversitesi, Fen Edebiyat Fakültesi, Psikoloji Bölümü, Işık University, Faculty of Arts and Sciences, Department of Psychology, İnci İzmir, Sevim Berrin, Ege Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Internal capsule Neuroimaging Audiology White matter 03 medical and health sciences 0302 clinical medicine Cognition Fractional anisotropy medicine Commission errors Attention deficit hyperactivity disorder Humans Psychiatry Child business.industry Neuropsychology medicine.disease White Matter 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Diffusion Tensor Imaging Attention Deficit Disorder with Hyperactivity DTI Anisotropy business commission errors human activities Sluggish cognitive tempo 030217 neurology & neurosurgery Diffusion MRI SCT |
| Popis: | Objective:The construct of Sluggish Cognitive Tempo (SCT) is characterized by daydreaming, mental confusion, staring blankly and hypoactivity. Our main goal was to explore neuropsychological differences in Attention Deficit Hyperactivity Disorder-Inattentive presentation (ADHD-IA) groups with and without SCT symptoms compared to healthy controls. After detecting specific neuropsychological differences, we examined white matter microstructure using Diffusion Tensor Imaging (DTI) data obtained from 3.0 Tesla MRI scans of the cases with SCT symptoms comparing to Typically Developing (TD) controls. Method:In this study, we included 24 cases in the ADHD-IA group with SCT symptoms, 57 cases in the ADHD-IA group without SCT symptoms and, 24 children in the TD group. We applied tract-based spatial statistics to the DTI measures for obtaining fractional anisotropy (FA), axial, radial and mean diffusivity (AD, RD, MD) to explore white matter differences for the whole brain. Results:Omission error scores and longer reaction time scores were specifically associated with inattention symptoms. Commission error scores were significantly and specifically related to SCT symptoms. Cases with SCT symptoms presented increased FA in the bilateral anterior and posterior limb of the internal capsule, bilateral cerebral peduncle, and the fornix than TD group. Conclusions:Neurobiological differences in ADHD cases are still relatively unexplored. We suggest that including an assessment for SCT in the neuropsychological and neuroimaging studies of ADHD may provide more consistent results. Ege University Scientific Research Projects Coordination UnitEge University [2016-TIP-047] This study was supported by Ege University Scientific Research Projects Coordination Unit (Project Number: 2016-TIP-047). |
| Databáze: | OpenAIRE |
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