Blood caspase-8 concentrations and mortality among septic patients
| Autor: | R. Ortiz-López, A. Perez, María M. Martín, Antonia Aránega Jiménez, Agustín F. González-Rivero, Verónica Gonzalez, Antonia Pérez-Cejas, Leonardo Lorente, M. Rodin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Caspase 8 business.industry Area under the curve 030208 emergency & critical care medicine Critical Care and Intensive Care Medicine medicine.disease Gastroenterology Sepsis 03 medical and health sciences Intensive Care Units 0302 clinical medicine 030228 respiratory system Spain Internal medicine Intensive care Area Under Curve Medicine Humans Hospital Mortality Prospective Studies business Extrinsic apoptosis |
| Zdroj: | Medicina intensiva. 46(1) |
| ISSN: | 2173-5727 |
| Popis: | Objective No data are available on blood caspase-8 concentrations (the initiator caspase in the extrinsic apoptosis pathway) in septic patients. The present study thus describes the blood caspase-8 concentrations in survivors and non-survivors, and examines the possible association between blood caspase-8 concentrations and mortality in septic patients. Design A prospective observational study was carried out. Setting Three Spanish Intensive Care Units. Patients Septic patients. Interventions Serum caspase-8 concentrations were determined at the diagnosis of sepsis. Main variable of interest Mortality after 30 days. Results Patients not surviving at day 30 (n = 81) compared to surviving patients (n = 140) showed higher serum caspase-8 levels (p 43.5 ng/ml and mortality (OR = 3.306; 95%CI = 1.619–6.753; p = 0.001). The area under the curve (AUC) for mortality predicted by serum caspase-8 levels was 67% (95% CI = 60–73%; p Conclusions The novel findings of our study were that blood caspase-8 concentrations are higher in non-survivors than in survivors, and that there is an association between blood caspase-8 concentrations and mortality in septic patients. |
| Databáze: | OpenAIRE |
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