Novel quinazolinones and enniatins from Fusarium lateritium Nees

Autor:	Xiao-Jin Xu, Youla S. Tsantrizos, Rosemary C. Hynes, Françoise Sauriol
Rok vydání:	1993
Předmět:	Biochemistry biology Fusarium lateritium Biological phenomenon Chemistry Organic Chemistry Botany General Chemistry Fungi imperfecti biology.organism_classification Pathogen Catalysis Eutypa armeniacae
Zdroj:	Canadian Journal of Chemistry. 71:1362-1367
ISSN:	1480-3291 0008-4042
DOI:	10.1139/v93-176
Popis:	Fusarium lateritium Nees is a natural antagonist of the plant pathogen Eutypa armeniacae. In an effort to show that this biological phenomenon is chemically mediated, the bioactive metabolites of F. lateritium were investigated. The cytotoxic alkaloids 2-(1-hydroxyethyl)-4(3H)quinazolinone (1) and 2-acetyl-4(3H)quinazolinone (2), and the three cyclohexadepsipeptides, enniatins B (3), B1 (4), and A1 (5), were isolated and characterized. Metabolites 3, 4, and 5 were found to exhibit strong antifungal activity against E. armeniacae. The structures of the novel metabolites 1 and 2 were elucidated by spectroscopic analysis and that of 2 was confirmed by X-ray crystallography. The absolute stereochemistry of 1 was investigated by 1H and I9F NMR analysis of its Mosher ester derivative.
Databáze:	OpenAIRE
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