Worsening of pain and function over 5 years in individuals with 'early' OA is related to structural damage: data from the Osteoarthritis Initiative and CHECK (Cohort Hip & Cohort Knee) study
| Autor: | Sita M A Bierma-Zeinstra, Janet Wesseling, Johannes W. J. Bijlsma, Rik Meijer, Margreet Kloppenburg |
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| Přispěvatelé: | General Practice, Orthopedics and Sports Medicine |
| Rok vydání: | 2015 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty WOMAC Immunology Pain Osteoarthritis General Biochemistry Genetics and Molecular Biology Cohort Studies Rheumatology Epidemiology Immunology and Allergy Medicine Humans Aged business.industry Incidence (epidemiology) Middle Aged medicine.disease Radiography Radiological weapon Cohort Physical therapy Disease Progression Female business Early phase Body mass index |
| Zdroj: | Annals of the Rheumatic Diseases, 74(2), 347-353 Annals of the Rheumatic Diseases, 74(2), 347-353. BMJ Publishing Group |
| ISSN: | 1468-2060 0003-4967 |
| Popis: | Objective To analyse the relation of joint damage on evolution of pain and physical functioning in two different cohorts of early phase of osteoarthritis (OA): Osteoarthritis Initiative (OAI) and Cohort Hip & Cohort Knee study (CHECK). Methods Longitudinal data of 4-5 years follow-up (= medium term) of CHECK study and OAI were used. The Western Ontario and McMaster Universities of Osteoarthritis Index (WOMAC) was used to measure pain and physical functioning. For comparison with CHECK a subgroup of the OAI Incidence cohort was selected, Generalised estimating equations were used and all models were adjusted for gender, Body Mass Index, age, amount of working hours, racial background and hip pain at baseline. Finally, an interaction term was added to assess a possible differential effect of radiological progression on evolution of pain and function in the two cohorts. Results At baseline, CHECK had less radiographic OA (K&L >= 2) compared with the OAI Incidence subgroup, but at follow-up CHECK had more radiographic change (51% vs 15% >= 1 K&L point increase; p= 2 grades of K&L in 4 or 5 years) is related to worsening of pain and function |
| Databáze: | OpenAIRE |
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