Selective Killing of Bacterial Persisters by a Single Chemical Compound without Affecting Normal Antibiotic-Sensitive Cells
| Autor: | Dongwoo Shin, Ji-Hee Suh, Bum Tae Kim, Jun Seob Kim, Sung-Koo Kim, Da-Hyeong Cho, Tae-Jun Yang, Paul Heo, Hee-Jong Lim, Ki-Sing Lee, Dae-Hyuk Kweon |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pharmacology
Programmed cell death Bacteria Chemical compound medicine.drug_class Antibiotics Reversion Bacterial persistence Biology Anti-Bacterial Agents Microbiology Chemical library chemistry.chemical_compound Infectious Diseases chemistry Pseudomonas aeruginosa Escherichia coli medicine Pharmacology (medical) Mechanisms of Action: Physiological Effects |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 55:5380-5383 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.00708-11 |
| Popis: | We show that 3-[4-(4-methoxyphenyl)piperazin-1-yl]piperidin-4-yl biphenyl-4-carboxylate (C10), screened out of a chemical library, selectively kills bacterial persisters that tolerate antibiotic treatment but does not affect normal antibiotic-sensitive cells. C10 led persisters to antibiotic-induced cell death by causing reversion of persisters to antibiotic-sensitive cells. This work is the first demonstration in which the eradication of bacterial persisters is based on single-chemical supplementation. The chemical should be versatile in elucidating the mechanism of persistence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|