Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy
| Autor: | Martina Vockerodt, Casper Paludan, Dieter Kube, Thomas Tuschl, Dorothee Schmid, Markus Landthaler, Christian Münz |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
CD4-Positive T-Lymphocytes
Proteasome Endopeptidase Complex T cell Antigen presentation Transfection Major histocompatibility complex Cell Line 03 medical and health sciences 0302 clinical medicine Antigen Cell Line Tumor Microsomes Phagosomes hemic and lymphatic diseases MHC class I Autophagy medicine Animals Humans Cell Line Transformed 030304 developmental biology Antigen Presentation B-Lymphocytes 0303 health sciences MHC class II Multidisciplinary biology Antigen processing Histocompatibility Antigens Class II Chloroquine Hydrogen-Ion Concentration MHC restriction Virology 3. Good health Cell biology medicine.anatomical_structure Epstein-Barr Virus Nuclear Antigens biology.protein Lysosomes 030215 immunology |
| Zdroj: | Science. 307:593-596 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | CD4 + T cells classically recognize antigens that are endocytosed and processed in lysosomes for presentation on major histocompatibility complex (MHC) class II molecules. Here, endogenous Epstein-Barr virus nuclear antigen 1 (EBNA1) was found to gain access to this pathway by autophagy. On inhibition of lysosomal acidification, EBNA1, the dominant CD4 + T cell antigen of latent Epstein-Barr virus infection, slowly accumulated in cytosolic autophagosomes. In addition, inhibition of autophagy decreased recognition by EBNA1-specific CD4 + T cell clones. Thus, lysosomal processing after autophagy may contribute to MHC class II–restricted surveillance of long-lived endogenous antigens including nuclear proteins relevant to disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |