Assessing adrenal function in primary care settings with a single sample subcutaneous glucagon test

Autor: Dexiang Gao, Rebecca Ratliff, Michael S. Kappy, Amanda Drake
Rok vydání: 2006
Předmět:
Blood Glucose
Male
Hypothalamo-Hypophyseal System
endocrine system
medicine.medical_specialty
Time Factors
Adolescent
Hydrocortisone
Pituitary Diseases
Adrenal Gland Diseases
Radioimmunoassay
Pituitary-Adrenal System
Dwarfism
Single sample
Primary care
Sensitivity and Specificity
Glucagon
Immunoenzyme Techniques
Glucagon test
Adrenocorticotropic Hormone
Hexokinase
Internal medicine
Adrenal Glands
Humans
Medicine
Adrenal function
Child
Growth Disorders
Dose-Response Relationship
Drug
Primary Health Care
business.industry
Adrenal gland
digestive
oral
and skin physiology
Infant
Newborn
Infant
Fasting
Hormones
Dose–response relationship
medicine.anatomical_structure
Endocrinology
Case-Control Studies
Child
Preschool
Pediatrics
Perinatology and Child Health
Female
business
hormones
hormone substitutes
and hormone antagonists
Zdroj: The Journal of Pediatrics. 149:682-686
ISSN: 0022-3476
Popis: Objective To test the efficacy of the low-dose glucagon test in assessing adrenal gland function. Study design Subcutaneous glucagon was used to assess the hypothalamo-pituitary-adrenal gland (HPA) axis in 215 healthy children. Concordance of this test with the low-dose intravenous ACTH test was established for 42 children. Glucagon testing was conducted for 150 minutes after subcutaneous glucagon administration and for 30 minutes after 1 μg intravenous ACTH. Results Mean peak serum cortisol concentrations were 22.4 ± 0.6 μg/dL (SEM) after subcutaneous glucagon and 20.0 ± 0.6 μg/dL after intravenous ACTH. Specificity of 95% was found at peak cortisol concentrations of 9.5 and 12.5 μg/dL for the glucagon and ACTH tests, respectively. Concordance between the glucagon and ACTH tests was 90.5%. Conclusions The glucagon test was found to be as good a test of the HPA axis as the ACTH test and had a 90.5% concordance with it. The ease of performing the glucagon test, namely, obtaining a single sample of blood 150 minutes after the subcutaneous administration of glucagon, makes it a useful method of assessing the HPA axis in primary care settings.
Databáze: OpenAIRE
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