Three-Dimensional Simulations of Reactive Gas Uptake in Single Airway Bifurcations
| Autor: | Ali Borhan, James S. Ultman, Adekemi B. Taylor |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Quantitative Biology::Tissues and Organs
Microfluidics Physics::Medical Physics Biomedical Engineering Thermodynamics Lung injury Computational fluid dynamics Models Biological Diffusion Physics::Fluid Dynamics symbols.namesake Imaging Three-Dimensional Ozone Animals Humans Computer Simulation Lung Bifurcation Air Pollutants geography geography.geographical_feature_category Pulmonary Gas Exchange Chemistry business.industry Reynolds number Mechanics Inlet Volumetric flow rate Flow conditions Models Chemical Respiratory Mechanics symbols business Airway |
| Zdroj: | Annals of Biomedical Engineering. 35:235-249 |
| ISSN: | 1573-9686 0090-6964 |
| Popis: | The pattern of lung injury induced by the inhalation of ozone (O(3)) depends on the dose delivered to different tissues in the airways. This study examined the distribution of O(3) uptake in a single, symmetrically branched airway bifurcation. Reaction in the epithelial lining fluid was assumed to be so rapid that O(3) concentration was negligible along the entire surface of the bifurcation wall. Three-dimensional numerical solutions of the continuity, Navier-Stokes and convection-diffusion equations were obtained for steady inspiratory and expiratory flows at Reynolds numbers ranging from 100 to 500. The total rate of O(3) uptake was found to increase with increasing flow rate during both inspiration and expiration. Hot spots of O(3) flux appeared at the carina of the bifurcation for virtually all inspiratory and expiratory Reynolds numbers considered in the simulations. At the lowest expiratory Reynolds number, however, the location of the maximum flux was shifted to the outer wall of the daughter branch. For expiratory flow, additional hot spots of flux were found on the parent branch wall just downstream of the branching region. In all cases, O(3) uptake in the single bifurcation was larger than that in a straight tube of equal inlet radius and wall surface area. This study provides insight into the effect of flow conditions on O(3) uptake and dose distribution in individual bifurcations. |
| Databáze: | OpenAIRE |
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