Improving Topical Skin Delivery of Monocrotaline Via Liposome Gel-based Nanosystems
| Autor: | Jian-dong Yu, Qi Liu, Chao-yuan Tang, Zhi Chen, Yang Xiong, Shuang Zheng, Enying Hu, Yan-Zhi Yin |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_treatment Administration Topical Skin Absorption Pharmaceutical Science 02 engineering and technology Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Delivery Systems medicine Glycerol Animals Nanotechnology Liposome Chromatography Monocrotaline Methylparaben Viscosity Vitamin E Buffer solution 021001 nanoscience & nanotechnology Box–Behnken design Rats Drug Liberation chemistry 030220 oncology & carcinogenesis Triethanolamine Liposomes 0210 nano-technology Citric acid Gels medicine.drug |
| Zdroj: | Current drug delivery. 16(10) |
| ISSN: | 1875-5704 |
| Popis: | Background: In this study, a liposomal gel based on a pH-gradient method was used to increase the skin-layer retention of monocrotaline (MCT) for topical administration. Methods: Using the Box-Behnken design, different formulations were designed to form liposome suspensions with optimal encapsulation efficiency (EE%) and stability factor (KE). In order to keep MCT in liposomes and accumulate in skin slowly and selectively, MCT liposome suspensions were engineered into gels. Results: A pH-gradient method was used to prepare liposome suspensions. The optimal formulation of liposome suspensions (encapsulation efficiency: 83.10 ± 0.21%) was as follows: MCT 12 mg, soybean phosphatidyl choline (sbPC) 200 mg, cholesterol (CH) 41 mg, vitamin E (VE) 5 mg, and citric acid buffer solution (CBS) 4.0 10 mL (pH 7.0). The final formulation of liposomal gels consisted of 32 mL liposome suspensions, 4.76 mL deionized water, 0.40 g Carbopol-940, 1.6 g glycerol, 0.04 g methylparaben, and a suitable amount of triethanolamine for pH value adjustment. The results of in vitro drug release showed that MCT in liposomal gels could be released in 12 h constantly in physiological saline as a Ritger-Peppas model. Compared with plain MCT in gel form, liposomal MCT in gel had higher skin retention in vitro. Conclusion: In this study, liposomal gels were formed for greater skin retention of MCT. It is potentially beneficial for reducing toxicities of MCT by topical administration with liposomal gel. |
| Databáze: | OpenAIRE |
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