Potential benefits of patchouli alcohol in prevention of human diseases: A mechanistic review

Autor:	Jihye Lee, Hee-Seop Lee, Seong-Ho Lee, Dmitriy Smolensky
Rok vydání:	2020
Předmět:	ERK Extracellular signal-Regulated Kinase HPU Helicobactor Pylori Urease IR Ischemia/reperfusion iNOS Inducible Nitric Oxide Synthase PERK Protein kinase R-like Endoplasmic Reticulum Kinase Alcohol C/EBPα CCAT/enhancer Binding Protein α RIP3 Receptor Interacting Serine/Threonine- Protein kinase3 CXCL11 C-X-C Motif Chemokine 11 IBD Inflammatory Bowel Disease DCNB 2 4-Dinitro-chlorobenzene IRE1 Inositol-requiring Enzyme 1 0302 clinical medicine ACE2 Angiotensin Converting Enzyme 2 Medicine 4E-BP1 Eukaryotic Translation Initiation Factor 4E Binding Protein 1 SOD Superoxide Dismutase 5-HT 5-Hydroxytryptamine LPS Lipopolysaccharide TLR2 Toll-like Receptor 2 media_common ER Estrogen Receptor IFNγ Interferon γ Nrf2 Nuclear Factor Erythroid 2-Related Factor 2 NF-κB Nuclear Factor κ-light-chain-enhancer of activated B cells VDCC Voltage-Dependent Ca2+ Channel Pogostemon SYN1 Synapsin-1 PXR Pregnane X Receptor 030220 oncology & carcinogenesis IP3R Inositol Triphosphate Receptor Sesquiterpenes PSD-95 Postsynaptic Density Protein 95 TPH1 Tryptophan Hydroxylase 1 Drug media_common.quotation_subject Immunology CUMS Chronic Unpredictable Mild Stress ZO-1 Zonula Occludens-1 Article WHO World Health Organization 03 medical and health sciences food ICAM-1 Intracellular Adhesion Molecule-1 Humans VLDL Very Low Density Lipoprotein Pharmacology IDO-1 Indoleamine 2 3-dioxygenease-1 TNFα Tumor Necrosis Factor α MAPK Mitogen-Activated Protein Kinase NO Nitric Oxide CAT Catalase 030104 developmental biology Patchouli alcohol mTOR Mammalian Target of Rapamycin chemistry PI3K Phosphoinositol-3 Kinase RdRp RNA-Dependent RNA Polymerase 0301 basic medicine CXCL10 C-X-C Motif Chemokine 10 PLpro Papain-like Protease Anti-Inflammatory Agents 3CLpro 3C-Like Protease PGE2 Prostaglandin E2 Health benefits COX2 Cyclooxygenase 2 MLKL Mixed Lineage Kinase Domain-Like Pseudokinase chemistry.chemical_compound 5-FU 5-Fluorouracil Immunology and Allergy CXCL9 C-X-C Motif Chemokine 9 eNOS Endothelial Nitric Oxide Synthase biology Traditional medicine respiratory system 5-HTP 5-Hydroxytryptophan VCAM-1 Vascular Cell Adhesion Molecule 1 NLRP3 NOD- LRR- and Pyrin Domain-containing Protein 3 Immunosuppressive Agents food.ingredient ATF6 Activating Transcription Factor 6 DSS Dextran Sulfate Sodium TXNIP Thioredoxin Interacting Protein ROCCs Receptor-operated Ca2+ Channels Functional food PA Patchouli Alcohol SCFA Short Chain Fatty Acid MDA Malondialdehyde Biological mechanisms RyRs Ryanodine Receptors Lung protection business.industry PHE Phenylephrine GSH-px Glutathione Peroxidase MMP9 Matrix Metalloproteinase 9 biology.organism_classification Antineoplastic Agents Phytogenic DTH Delayed Type Hypersensitivity PPARγ Peroxisome Proliferator Activated Receptor γ HO-1 Heme Oxidase-1 Molecular targets EGFR Epidermal Growth Factor Receptor Kyn L-Kynurenine MCP-1 Monocyte Chemoattractant Protein-1 Patchouli business human activities ROS Reactive Oxygen Species
Zdroj:	International Immunopharmacology
ISSN:	1567-5769
Popis:	Highlights • Patchouli alcohol (PA) is a bioactive component in essential oil extracted from Pogostemon cablin. • The present review provides the scientific mechanisms for health beneficial activities of PA in diverse disease models. • PA possesses diverse health beneficial activities. Patchouli alcohol (PA), a tricyclic sesquiterpene, is a dominant bioactive component in oil extracted from the aerial parts of Pogostemon cablin (patchouli). Diverse beneficial activities have been reported, including anti-influenza virus, anti-depressant, anti-nociceptive, vasorelaxation, lung protection, brain protection, anti-ulcerogenic, anti-colitis, pre-biotic-like, anti-inflammatory, anti-cancer and protective activities against metabolic diseases. However, detailed mechanistic studies are required to explore the possibility of developing PA as a functional food material or promising drug for the prevention and treatment of human diseases. This review highlights multiple molecular targets and working mechanisms by which PA mediates health benefits.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e0bef40b542aa0945c4a6b4a7afa05 https://doi.org/10.1016/j.intimp.2020.107056 Zobrazit plný text záznamu Full Text from ScienceDirect