The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine
| Autor: | Mehrdad Kiani, Claire Higgins, Benjamin Almquist, Mohammad Ali Kiani |
|---|---|
| Přispěvatelé: | Medical Research Council (MRC), Wellcome Trust, Rosetrees Trust, British Skin Foundation, Diabetes Research & Wellness Foundation |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell type Biomedical Engineering 02 engineering and technology Biology Regenerative medicine Article Biomaterials 03 medical and health sciences Follicle Keratin medicine chemistry.chemical_classification integumentary system Neurogenesis Anatomy 021001 nanoscience & nanotechnology Hair follicle 3. Good health Cell biology 030104 developmental biology medicine.anatomical_structure chemistry Stem cell 0210 nano-technology Wound healing |
| Zdroj: | ACS biomaterials scienceengineering. 4(4) |
| ISSN: | 2373-9878 |
| Popis: | The hair follicle is one of only two structures within the adult body that selectively degenerates and regenerates, making it an intriguing organ to study and use for regenerative medicine. Hair follicles have been shown to influence wound healing, angiogenesis and neurogenesis, and harbor distinct populations of stem cells; this has led to cells from the follicle being used in clinical trials for tendinosis and chronic ulcers. In addition, keratin produced by the follicle in the form of a hair fiber provides an abundant source of biomaterials for regenerative medicine. In this review, we provide an overview of the structure of a hair follicle, explain the role of the follicle in regulating the microenvironment of skin and the impact on wound healing, explore individual cell types of interest for regenerative medicine, and cover several applications of keratin-based biomaterials. |
| Databáze: | OpenAIRE |
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