α-Adducin gene promoter DNA methylation and the risk of essential hypertension

Autor:	Mohamed M. El-Shabrawi, Hamdy Omar, Nervana Bayoumy, Ola Farouk Leheta
Rok vydání:	2017
Předmět:	Male 0301 basic medicine medicine.medical_specialty Physiology 030204 cardiovascular system & hematology Biology Essential hypertension 03 medical and health sciences Sex Factors 0302 clinical medicine Risk Factors Internal medicine Internal Medicine medicine Humans Aspartate Aminotransferases Promoter Regions Genetic Gene Case-control study Promoter General Medicine Methylation DNA Methylation Middle Aged medicine.disease Molecular biology 030104 developmental biology Endocrinology ADD1 CpG site Case-Control Studies Hypertension DNA methylation Calmodulin-Binding Proteins CpG Islands Female Essential Hypertension
Zdroj:	Clinical and Experimental Hypertension. 39:764-768
ISSN:	1525-6006 1064-1963
Popis:	This study was conducted to test the association between promoter DNA methylation of α-Adducin (ADD1) gene and the risk of essential hypertension (EH). A total of 150 EH patients and 100 aged- and gender-matched controls were investigated. DNA methylation levels of five cytosine-phosphate-guanine (CpG) dinucleotides on ADD1 promoter were measured employing bisulfite pyrosequencing technology. Our results showed that females have a higher ADD1 DNA methylation than males and a significantly lower CpG1 methylation level is associated with increased risk of EH among them. As for males, a significant association between lower CpG2-5 methylation levels and increased risk of EH was shown. In addition, CpG2-5 methylation was found to be a highly significant predictor for EH among males. In females, CpG1 methylation was considered a predictor of hypertension. No significant correlations were found with biochemical measures, apart from the concentration of aspartate aminotransferase which was inversely correlated with ADD1 CpG2-5 methylation levels among female controls (r = -0.703). These findings highlight that ADD1 methylation may have a contributing role in the pathogenesis of EH with varying implications for both genders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52de14cc7c2242524454450dc6fb2987 https://doi.org/10.1080/10641963.2017.1324481 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.