Compensatory growth in runt pigs is not mediated by insulin-like growth factor I
| Autor: | S V Radecki, Gretchen Ritacco, P A Schoknecht |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Baseline group Swine medicine.medical_treatment Radioimmunoassay Biology Kidney Eating Insulin-like growth factor Gastrocnemius muscle Internal medicine Genetics medicine Animals Insulin Compensatory growth (organism) RNA Messenger Insulin-Like Growth Factor I Muscle Skeletal Brain Chemistry Messenger RNA Body Weight Runt Brain Nuclease protection assay Organ Size General Medicine Endocrinology Animals Newborn Liver Autoradiography Animal Science and Zoology Food Science Rate of growth |
| Zdroj: | Journal of Animal Science. 75:1237 |
| ISSN: | 0021-8812 |
| DOI: | 10.2527/1997.7551237x |
| Popis: | Runt pigs grow more slowly and never reach the same body weight as age-matched littermates. We hypothesized that IGF-I would be reduced in the runts and that postnatal nutrition would alter IGF-I concentration and tissue expression. Runt and control littermates were removed from 20 crossbred sows 20 to 28 h after birth. Tissues were collected from a baseline group (n = 4). The remaining pigs were fed porcine milk replacer at either 70 or 120 g/kg BW for 14 d (n = 8). Feed intake and body weight were measured daily, with plasma samples collected by jugular venipuncture throughout the experiment. Expression of IGF-I mRNA was measured in the liver and gastrocnemius with an RNase protection assay. At d 0, runts were significantly smaller than controls in all measurements, except brain weight. During the 14 d, the relative rate of growth was significantly faster and more efficient in runts than in controls; however, runts never attained the same absolute body weight as controls. Circulating IGF-I was significantly reduced at d 0 but was similar to that in controls by d 2 of feeding. The IGF-I mRNA expression in liver or gastrocnemius muscle was not different between control and runts at d 0 or 14 and was not affected by dietary intake. This study has shown that runt pigs grow in a compensatory manner for at least the first 2 wk of life. However, this growth response does not seem to be mediated by IGF-I. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|