Brain-Derived Neurotrophic Factor in Central Nervous System Myelination: A New Mechanism to Promote Myelin Plasticity and Repair

Autor: Jessica L. Fletcher, Junhua Xiao, Simon S. Murray
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Central Nervous System
0301 basic medicine
Review
Tropomyosin receptor kinase B
Catalysis
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
Myelin
0302 clinical medicine
Neurotrophic factors
Demyelinating disease
medicine
Animals
Humans
Receptor
trkB
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Myelin Sheath
Spectroscopy
Brain-derived neurotrophic factor
Neuronal Plasticity
biology
Brain-Derived Neurotrophic Factor
Organic Chemistry
neurotrophin
TrkB
myelination
General Medicine
medicine.disease
Oligodendrocyte
Nerve Regeneration
Computer Science Applications
030104 developmental biology
medicine.anatomical_structure
BDNF
nervous system
lcsh:Biology (General)
lcsh:QD1-999
biology.protein
Neuroscience
Neural development
030217 neurology & neurosurgery
oligodendrocyte
Neurotrophin
Zdroj: International Journal of Molecular Sciences, Vol 19, Iss 12, p 4131 (2018)
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: Brain-derived neurotrophic factor (BDNF) plays vitally important roles in neural development and plasticity in both health and disease. Recent studies using mutant mice to selectively manipulate BDNF signalling in desired cell types, in combination with animal models of demyelinating disease, have demonstrated that BDNF not only potentiates normal central nervous system myelination in development but enhances recovery after myelin injury. However, the precise mechanisms by which BDNF enhances myelination in development and repair are unclear. Here, we review some of the recent progress made in understanding the influence BDNF exerts upon the myelinating process during development and after injury, and discuss the cellular and molecular mechanisms underlying its effects. In doing so, we raise new questions for future research.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje