Brain-Derived Neurotrophic Factor in Central Nervous System Myelination: A New Mechanism to Promote Myelin Plasticity and Repair
Autor: | Jessica L. Fletcher, Junhua Xiao, Simon S. Murray |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Central Nervous System
0301 basic medicine Review Tropomyosin receptor kinase B Catalysis Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences Myelin 0302 clinical medicine Neurotrophic factors Demyelinating disease medicine Animals Humans Receptor trkB Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Myelin Sheath Spectroscopy Brain-derived neurotrophic factor Neuronal Plasticity biology Brain-Derived Neurotrophic Factor Organic Chemistry neurotrophin TrkB myelination General Medicine medicine.disease Oligodendrocyte Nerve Regeneration Computer Science Applications 030104 developmental biology medicine.anatomical_structure BDNF nervous system lcsh:Biology (General) lcsh:QD1-999 biology.protein Neuroscience Neural development 030217 neurology & neurosurgery oligodendrocyte Neurotrophin |
Zdroj: | International Journal of Molecular Sciences, Vol 19, Iss 12, p 4131 (2018) International Journal of Molecular Sciences |
ISSN: | 1422-0067 |
Popis: | Brain-derived neurotrophic factor (BDNF) plays vitally important roles in neural development and plasticity in both health and disease. Recent studies using mutant mice to selectively manipulate BDNF signalling in desired cell types, in combination with animal models of demyelinating disease, have demonstrated that BDNF not only potentiates normal central nervous system myelination in development but enhances recovery after myelin injury. However, the precise mechanisms by which BDNF enhances myelination in development and repair are unclear. Here, we review some of the recent progress made in understanding the influence BDNF exerts upon the myelinating process during development and after injury, and discuss the cellular and molecular mechanisms underlying its effects. In doing so, we raise new questions for future research. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |