Recovery of an Interferon-Like Substance from Cerebrospinal Fluid
| Autor: | Ion Gresser, Kiarash Naficy |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Amnion
business.industry Aseptic meningitis medicine.disease Meningitis Viral General Biochemistry Genetics and Molecular Biology Virus Cerebrospinal fluid medicine.anatomical_structure Central Nervous System Diseases Interferon Immunology Viral meningitis Humans Medicine Meningitis Interferons Child business Encephalitis Cerebrospinal Fluid medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 117:285-289 |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | SummaryOne hundred and eighty-one cerebrospinal fluids from 152 patients with infectious and non-infectious diseases of the central nervous system were tested for inter-feron. Thirty-two specimens from 28 patients contained a viral inhibitory factor similar to interferon, as assayed in primary cultures of human amnion cells “challenged” with Sind-bis virus. The cerebrospinal fluids from 23 of 58 patients with probable viral meningitis were inhibitory, while the CSFs from only 3 of 25 patients with bacterial meningitis and 2 of 69 patients with non-infectious diseases of the CNS were positive. There was a correlation between leucocyte concentration in the CSF of patients with aseptic meningitis and presence of the interferon-like substance. The source of this inhibitor in the CSF is discussed.We gratefully acknowledge the constant help and guidance of Dr. J. F. Enders during these investigations and in preparation of this article. We should also like to express our gratitude to Miss T. Mullin of the Record... |
| Databáze: | OpenAIRE |
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