Are Sub-Saharan epileptic people less photosensitive? A Senegalese study of photoparoxysmal response in a reference epilepsy centre
Autor: | Amadou Gallo Diop, Moustapha Ndiaye, Lala Bouna Seck, Dènahin Hinnoutondji Toffa, Annick Melanie Magnerou, Anna Modji Basse, Adjaratou Dieynabou Sow |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Sub saharan Adolescent Electroencephalography Clinical neurophysiology Young Adult Epilepsy Seizures Epidemiology medicine Humans Photosensitivity Disorders Generalized epilepsy Intermittent photic stimulation Child Africa South of the Sahara medicine.diagnostic_test business.industry Infant General Medicine Middle Aged medicine.disease Senegal Neurology Child Preschool Epilepsy Generalized Female Neurology (clinical) Eye closure business Photic Stimulation |
Zdroj: | Epileptic Disorders. 22:610-622 |
ISSN: | 1950-6945 1294-9361 |
Popis: | The photoparoxysmal response (PPR) is defined as the occurrence of generalized spike, spike-wave or polyspike-wave discharges consistently elicited by intermittent photic stimulation (IPS). PPR is not well studied in Sub-Saharan African people. We prospectively studied the epidemiological, clinical, and EEG characteristics of PPR among consecutive patients recorded at the clinical neurophysiology unit of Fann University Hospital (Dakar, Senegal). Among 6,808 EEG recordings including 3,065 pathological EEGs, we collected 56 EEGs with PPR (0.8% of all recorded EEGs and 1.8% of anormal EEGs), from 31 women and 25 men (sex ratio: 0.8). The mean age was 13.3 years (range: 8 months to 59 years). The peak of photosensitivity was found in the range of 6 to 10 years. Of the PPR cases, 12 had clinical manifestations during IPS. Generalized epilepsy was diagnosed in 23 (41%) patients and 18 (32%) had focal epilepsies. The most epileptogenic stimulation frequencies were between 12 and 24 Hz (range: 1-28 Hz). PPR were mainly triggered during eye closure (64%), and 41 patients (73% of PPR cases) were classified as Type 4 (Waltz classification). Our results confirm lower rates of photosensitivity in African Sub-Saharan people compared with others. Although the current data do not support a role of short-term ambient light levels, subject to consistent data from larger cohorts, it may be interesting to study the probable epigenetic-mediated protective role of sunshine against photosensitivity. |
Databáze: | OpenAIRE |
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