Adjuvant treatment and analysis of failures in patients with high-risk FIGO Stage Ib-II endometrial cancer: an Italian multicenter retrospective study (CTF study)
| Autor: | Benedetta Sostegni, Stefania Cosio, Renza Cristofani, A. Bellicini, Luca Fuso, T Maggino, Paolo Zola, Enrico Sartori, Fabio Landoni, Angiolo Gadducci |
|---|---|
| Přispěvatelé: | Gadducci, A, Cosio, S, Landoni, F, Maggino, T, Zola, P, Sostegni, B, Bellicini, A, Fuso, L, Cristofani, R, Sartori, E |
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Ovariectomy Urology Hysterectomy Obstetrics and gynaecology Endometrial cancer Retrospective Studie Recurrence medicine 80 and over Chemotherapy Humans Endometrial Neoplasm Adjuvant Aged Neoplasm Staging Retrospective Studies Aged 80 and over Radiotherapy business.industry Obstetrics and Gynecology Retrospective cohort study Lymphadenectomy Chemoradiotherapy Chemoradiotherapy Adjuvant Middle Aged medicine.disease Surgery Endometrial Neoplasms Female Italy Lymph Node Excision Neoplasm Recurrence Local Treatment Outcome Oncology Radiation therapy Neoplasm Recurrence Local business Human |
| Zdroj: | Gynecologic oncology. 134(1) |
| ISSN: | 1095-6859 |
| Popis: | Objectives The purpose of this retrospective study was to assess the clinical outcome of patients with high-risk, early-stage endometrioid endometrial cancer (stage Ib or II with myometrial invasion > 50%, grade 2-3). Methods We assessed 192 patients who underwent hysterectomy, bilateral salpingo-oophorectomy and pelvic lymphadenectomy, had histologically negative pelvic nodes, and had negative CT findings for aortic node involvement. Results Tumor relapsed in 36 patients after a median time of 21.2 months. The recurrence was vaginal in 7 (19.4%), distant in 16 (44.4%), aortic in 8 (22.2%), and involved multiple sites in 5 (13.9%). There was a trend to a lower vaginal recurrence rate in the 143 patients who received adjuvant radiotherapy (+ chemotherapy) compared with the 46 who did not (2.1% versus 8.7%). Distant or aortic recurrences were lower in the 37 patients who received adjuvant chemotherapy (+ radiotherapy) than in the 152 who did not (2.7% versus 18.4%, p = 0.02). Of the 29 patients who received sequential adjuvant chemotherapy and radiotherapy, none developed local recurrence and only one had distant recurrence. There was a trend for a better 5-year progression-free survival and overall survival for the patients who received chemotherapy (+ radiotherapy) compared with those who did not (86.0% versus 71.3%, and 92.3% versus 75.6%, respectively). Conclusions Our data appear to suggest that adjuvant chemotherapy reduces the risk of distant or aortic recurrences and that sequential adjuvant chemotherapy and radiotherapy achieve an excellent local and distant control of disease in these clinical settings. © 2014 Published by Elsevier Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect