P07.11 Advanced MRI increases accuracy for glioblastoma recurrence diagnosis: Single institution thresholds and validation of MR spectroscopy and diffuse weighted MR imaging
| Autor: | Radim Jančálek, Petr Pospíšil, Tomáš Kazda, Martin Bulik |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
In vivo magnetic resonance spectroscopy
Cancer Research business.industry P07 Neuroimaging of brain tumours medicine.disease Mr imaging 03 medical and health sciences 0302 clinical medicine Oncology 030220 oncology & carcinogenesis medicine Neurology (clinical) Single institution business Nuclear medicine 030217 neurology & neurosurgery Glioblastoma |
| Popis: | Accurate identification of glioblastoma progression remains unmet clinical need. The aim of this prospective single-institutional study is to determine and validate thresholds for metabolite concentrations at MR spectroscopy (MRS) and values of apparent diffusion coefficient (ADC) for distinguishing between tumor recurrence and pseudoprogression. Thirty-nine patients after standard treatment of glioblastoma underwent advanced imaging by MRS and ADC at the time of suspected recurrence at the median time to progression 6.7 months. The highest significant sensitivity and specificity to call glioblastoma recurrence was observed for the total choline (tCho) to total N-acetylaspartate (tNAA) metabolite ratio with threshold ≥1.3 (sensitivity 100.0% and specificity 94.7%). ADCmean value higher than 1313 × 10E−6 mm2/s was associated with pseudoprogression (sensitivity 98.3%, specificity 100.0%). The combination of MRS focused on tCho/tNAA metabolic ratio and ADCmean value represents imaging methods applicable to non-invasive differentiation between glioblastoma recurrence and pseudoprogression. However, institutional definition and validation of thresholds for differential diagnostics is needed for implementing these multimodal imaging techniques into clinical practice as well as clinical trials for elimination of setup errors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|