Manoeuvrability and biocompatibility of endodontic tricalcium silicate-based putties
| Autor: | Franklin R. Tay, M. Meng, Brian E. Bergeron, Stephanie J. Sidow, Jeffrey N. Steed, Li Na Niu, Qin Sun, Jing zhi Ma |
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| Rok vydání: | 2021 |
| Předmět: |
Cement
Materials science Biocompatibility Silicates Perforation (oil well) Oxides 030206 dentistry Dynamic mechanical analysis Calcium Compounds Root Canal Filling Materials 03 medical and health sciences 0302 clinical medicine Putty Dental pulp stem cells Indentation Materials Testing Humans 030212 general & internal medicine Zinc Oxide-Eugenol Cement General Dentistry Elastic modulus Biomedical engineering |
| Zdroj: | Journal of Dentistry. 104:103530 |
| ISSN: | 0300-5712 |
| DOI: | 10.1016/j.jdent.2020.103530 |
| Popis: | Objectives The present study evaluated the indentation depth, storage modulus and biocompatibility of an experimental endodontic putty designed for endodontic perforation repair and direct pulp-capping (NeoPutty). The results were compared with the properties associated with the commercially available EndoSequence BC RRM Putty (ES Putty). Methods Indentation depth was measured by a profilometer following indentation with the 1/4 lb Gilmore needle. Elastic modulus was evaluated using a strain-controlled rheometer. The effects of eluents derived from these two putties were examined on the viability and proliferation of human dental pulp stem cells (hDPSCs) and human periodontal ligament fibroblasts (hPDLFs), before (1 st testing cycle) and after complete setting (2nd testing cycle). Results The ES Putty became more difficult to ident and acquired a larger storage modulus after exposure to atmospheric moisture. Biocompatibility results indicated that both putties were relatively more cytotoxic than the bioinert Teflon negative control, but much less cytotoxic than the zinc oxide–eugenol cement negative control. NeoPutty was less cytotoxic than ES putty in the 1st testing cycle, particularly with hDPSCs. Both putties exhibited more favourable cytotoxicity profiles after complete setting. Conclusions NeoPutty has a better window of maneuverability after exposure to atmospheric moisture. From an in vitro cytotoxicity perspective, the NeoPutty may be considered more biocompatible than ES putty. Clinical significance The experimental NeoPutty is biocompatible and is capable of reducing the frustration of shortened shelf life when jar-stored endodontic putties are exposed to atmospheric moisture during repeated opening of the lid for clinical retrieval. |
| Databáze: | OpenAIRE |
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