Dopamine modulates the reward experiences elicited by music
| Autor: | Helena Alicart, Jordi Riba, Pablo Ripollés, Rosa M. Antonijoan, Alba Gomez-Andres, Robert J. Zatorre, Marta Valle, Laura Ferreri, Antoni Rodríguez-Fornells, Ernest Mas-Herrero, Josep Marco-Pallarés, Guillem Olivé |
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| Přispěvatelé: | RS: FPN NPPP II, Section Psychopharmacology |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Levodopa media_common.quotation_subject Emotions NUCLEUS-ACCUMBENS Administration Oral pleasure Placebo Pleasure Young Adult motivation Dopamine Commentaries medicine Humans music EMOTIONAL RESPONSES BRAIN ANTICIPATION reward media_common Multidisciplinary Risperidone CORRELATE LEVODOPA Dopaminergic Dopamine antagonist Cognition Placebo Effect humanities RECEPTOR OCCUPANCY SEMANTIC ACTIVATION LIKING Dopamine Agonists Auditory Perception Female dopamine Psychology Neuroscience medicine.drug |
| Zdroj: | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Proceedings of the National Academy of Sciences of the United States of America, 116(9), 3793-3798. National Academy of Sciences |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1811878116 |
| Popis: | Understanding how the brain translates a structured sequence of sounds, such as music, into a pleasant and rewarding experience is a fascinating question which may be crucial to better understand the processing of abstract rewards in humans. Previous neuroimaging findings point to a challenging role of the dopaminergic system in music-evoked pleasure. However, there is a lack of direct evidence showing that dopamine function is causally related to the pleasure we experience from music. We addressed this problem through a double blind within-subject pharmacological design in which we directly manipulated dopaminergic synaptic availability while healthy participants (n = 27) were engaged in music listening. We orally administrated to each participant a dopamine precursor (levodopa), a dopamine antagonist (risperidone), and a placebo (lactose) in three different sessions. We demonstrate that levodopa and risperidone led to opposite effects in measures of musical pleasure and motivation: while the dopamine precursor levodopa, compared with placebo, increased the hedonic experience and music-related motivational responses, risperidone led to a reduction of both. This study shows a causal role of dopamine in musical pleasure and indicates that dopaminergic transmission might play different or additive roles than the ones postulated in affective processing so far, particularly in abstract cognitive activities. |
| Databáze: | OpenAIRE |
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