In and out: Traffic and dynamics of thrombopoietin receptor
| Autor: | Anita Roy, Saurabh Shrivastva, Saadia Naseer |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Golgi Apparatus
Reviews Review myeloproliferation Biology Structure-Activity Relationship Megakaryocyte Drug Discovery medicine Animals Humans Thrombopoiesis Thrombopoietin TYK2 Kinase traffic Thrombopoietin receptor thrombopoietin receptor Hematopoietic stem cell Cell Biology Janus Kinase 2 Hematopoietic Stem Cells receptor dimerization Protein Transport Haematopoiesis medicine.anatomical_structure Gene Expression Regulation JAK2 Mutation Cancer research Molecular Medicine Disease Susceptibility Bone marrow Protein Multimerization Stem cell Calreticulin Receptors Thrombopoietin Protein Binding Signal Transduction |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 1582-1838 |
| Popis: | Thrombopoiesis had long been a challenging area of study due to the rarity of megakaryocyte precursors in the bone marrow and the incomplete understanding of its regulatory cytokines. A breakthrough was achieved in the early 1990s with the discovery of the thrombopoietin receptor (TpoR) and its ligand thrombopoietin (TPO). This accelerated research in thrombopoiesis, including the uncovering of the molecular basis of myeloproliferative neoplasms (MPN) and the advent of drugs to treat thrombocytopenic purpura. TpoR mutations affecting its membrane dynamics or transport were increasingly associated with pathologies such as MPN and thrombocytosis. It also became apparent that TpoR affected hematopoietic stem cell (HSC) quiescence while priming hematopoietic stem cells (HSCs) towards the megakaryocyte lineage. Thorough knowledge of TpoR surface localization, dimerization, dynamics and stability is therefore crucial to understanding thrombopoiesis and related pathologies. In this review, we will discuss the mechanisms of TpoR traffic. We will focus on the recent progress in TpoR membrane dynamics and highlight the areas that remain unexplored. |
| Databáze: | OpenAIRE |
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