Surface-initiated atom-transfer radical polymerization (SI-ATRP) of bactericidal polymer brushes on poly(lactic acid) surfaces
| Autor: | David M. Collard, Zhishuai Geng, Pranav P. Kalelkar, Bronson Cox, M. G. Finn |
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| Rok vydání: | 2022 |
| Předmět: |
Polymers
Surface Properties Polyesters Radical polymerization macromolecular substances Methacrylate Chloride Polymerization chemistry.chemical_compound Colloid and Surface Chemistry stomatognathic system Polymer chemistry medicine Physical and Theoretical Chemistry chemistry.chemical_classification Chemistry Atom-transfer radical-polymerization technology industry and agriculture Halogenation Surfaces and Interfaces General Medicine Polymer respiratory system Grafting Lactic acid lipids (amino acids peptides and proteins) Biotechnology medicine.drug |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 211:112242 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2021.112242 |
| Popis: | We have modified the surface of poly(lactic acid) (PLA) by bromination in the presence of N-bromosuccinimide (NBS) under UV irradiation. This new approach to impart functionality to the surface does not effect the bulk of the material. Brominated PLA surfaces served as initiators for atom-transfer radical polymerization (SI-ATRP) of 2-(methacryloyloxy)ethyl]trimethylammonium chloride, a quaternary ammonium methacrylate (QMA). Grafting of poly(QMA) brushes rendered PLA films hydrophilic and these films displayed a three-order of magnitude increase in antimicrobial efficacy against Gram-negative bacteria such as Escherichia coli as compared to unmodified PLA. The two-step strategy described here to modify PLA surface represents a useful route to modified PLA materials for biomedical and antimicrobial packaging applications. |
| Databáze: | OpenAIRE |
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