Cardiac MRI to visualize myocardial damage after ST-segment elevation myocardial infarction
| Autor: | Robin Nijveldt, Sebastiaan C.A.M. Bekkers, Henk Everaars, Lara S. F. Konijnenberg, Niels van Royen, Robert A. Kloner, Casper W. H. Beijnink, Saloua El Messaoudi, Raymond J. Kim, Albert C. van Rossum, Nina W. van der Hoeven |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] PERCUTANEOUS CORONARY INTERVENTION SIGNAL INTENSITY Fibrosis Internal medicine Edema medicine Humans ST segment Late gadolinium enhancement Radiology Nuclear Medicine and imaging Myocardial infarction cardiovascular diseases LATE GADOLINIUM-ENHANCEMENT INTRAMYOCARDIAL HEMORRHAGE QUANTITATIVE ASSESSMENT business.industry Myocardium Reproducibility of Results Percutaneous coronary intervention Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16] Heart Infarct size medicine.disease Magnetic Resonance Imaging PROGNOSTIC VALUE CARDIOVASCULAR MAGNETIC-RESONANCE MICROVASCULAR OBSTRUCTION PORCINE MODEL Cardiology CONTRAST ENHANCEMENT cardiovascular system ST Elevation Myocardial Infarction medicine.symptom business Reperfusion injury |
| Zdroj: | Beijnink, C W H, van der Hoeven, N W, Konijnenberg, L S F, Kim, R J, Bekkers, S C A M, Kloner, R A, Everaars, H, el Messaoudi, S, van Rossum, A C, van Royen, N & Nijveldt, R 2021, ' Cardiac MRI to visualize myocardial damage after ST-segment elevation myocardial infarction : A review of its histologic validation ', Radiology, vol. 301, no. 1, pp. 4-18 . https://doi.org/10.1148/radiol.2021204265 Radiology, 301, 4-18 Radiology, 301, 1, pp. 4-18 |
| ISSN: | 0033-8419 |
| DOI: | 10.1148/radiol.2021204265 |
| Popis: | Item does not contain fulltext Cardiac MRI is a noninvasive diagnostic tool using nonionizing radiation that is widely used in patients with ST-segment elevation myocardial infarction (STEMI). Cardiac MRI depicts different prognosticating components of myocardial damage such as edema, intramyocardial hemorrhage (IMH), microvascular obstruction (MVO), and fibrosis. But how do cardiac MRI findings correlate to histologic findings? Shortly after STEMI, T2-weighted imaging and T2* mapping cardiac MRI depict, respectively, edema and IMH. The acute infarct size can be determined with late gadolinium enhancement (LGE) cardiac MRI. T2-weighted MRI should not be used for area-at-risk delineation because T2 values change dynamically over the first few days after STEMI and the severity of T2 abnormalities can be modulated with treatment. Furthermore, LGE cardiac MRI is the most accurate method to visualize MVO, which is characterized by hemorrhage, microvascular injury, and necrosis in histologic samples. In the chronic setting post-STEMI, LGE cardiac MRI is best used to detect replacement fibrosis (ie, final infarct size after injury healing). Finally, native T1 mapping has recently emerged as a contrast material-free method to measure infarct size that, however, remains inferior to LGE cardiac MRI. Especially LGE cardiac MRI-defined infarct size and the presence and extent of MVO may be used to monitor the effect of new therapeutic interventions in the treatment of reperfusion injury and infarct size reduction. © RSNA, 2021 Online supplemental material is available for this article. |
| Databáze: | OpenAIRE |
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