Circulating CD34⁺ progenitor cells and growth factors in patients treated with PCI for acute myocardial infarction or stable angina pectoris

Autor:	Kirsti Solberg Landsverk, Harald Arnesen, Pavel Hoffmann, Svein Solheim, Haakon Kiil Grøgaard, Arnfinn Ilebekk, Ingebjørg Seljeflot
Rok vydání:	2011
Předmět:	Adult Male medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Myocardial Infarction Antigens CD34 Angina Pectoris Angina Angioplasty Internal medicine medicine Humans cardiovascular diseases Myocardial infarction Angioplasty Balloon Coronary Insulin-Like Growth Factor I Aged business.industry Hepatocyte Growth Factor Percutaneous coronary intervention General Medicine Middle Aged medicine.disease Chemokine CXCL12 Surgery Adult Stem Cells surgical procedures operative Conventional PCI Circulatory system Cardiology Female Stents business Perfusion TIMI
Zdroj:	Scandinavian journal of clinical and laboratory investigation. 71(4)
ISSN:	1502-7686
Popis:	To differentiate the effect of myocardial infarction from the effect of percutaneous coronary intervention (PCI) on the circulatory profiles of CD34(+) cells and growth factors in patients with ST-elevation myocardial infarction (STEMI).Twenty patients with STEMI and 10 with angina pectoris (AP) were included. All were treated with PCI. Blood was drawn before PCI in the AP group, and after 3 and 12 hours, and 1, 3, 5, 7 and 14 days after PCI in both groups. In STEMI patients, correlation analyses between TIMI myocardial perfusion grade (TMP-grade) and circulating CD34(+) cells were also assessed.Circulating CD34(+) cells increased from day 1 to days 5 and 7 after PCI only in STEMI patients (p0.05). Between-group analyses revealed a borderline significant difference in change in SDF-1α concentrations from 3 h to 14 days after PCI (p = 0.05), and SDF-1α was significantly higher in STEMI patients 14 days after PCI (p0.05). In both groups, peak HGF concentrations were observed 3 h after PCI, whereas IGF-1 increased in AP patients only, 3 h after PCI (p0.005). TIMI perfusion grade was negatively correlated to the circulating number of CD34(+) cells 5 days after PCI (r =-0.69, p0.005).After PCI, STEMI patients have significantly higher numbers of circulating CD34(+) progenitor cells compared to patients with AP. STEMI results in a significant increase in SDF-1α after 14 days, and the increase at this time may indicate a favorable environment for progenitor cell therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cb7ac18a19d7d3a880cf32629b7432 https://pubmed.ncbi.nlm.nih.gov/21463159 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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