State-specific gating of salient cues by midbrain dopaminergic input to basal amygdala
| Autor: | Veronica E. Diaz, Andrew Lutas, Mark L. Andermann, Crista Carty, Vanessa Flores-Maldonado, Osama Alturkistani, Hakan Kucukdereli, Kayla Fernando, Arthur U. Sugden |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Mice Transgenic Gating Biology Amygdala Article Midbrain 03 medical and health sciences Mice 0302 clinical medicine Punishment Reward Dopamine Neural Pathways medicine Animals Dopamine Plasma Membrane Transport Proteins General Neuroscience Dopaminergic Neurons Dopaminergic Ventral Tegmental Area Sensory Gating Associative learning Ventral tegmental area 030104 developmental biology medicine.anatomical_structure nervous system Excitatory postsynaptic potential Visual Perception Female Cues Calcium-Calmodulin-Dependent Protein Kinase Type 2 Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery Photic Stimulation medicine.drug |
| Zdroj: | Nature neuroscience |
| ISSN: | 1546-1726 1097-6256 |
| Popis: | Basal amygdala (BA) neurons guide associative learning via acquisition of responses to stimuli that predict salient appetitive or aversive outcomes. We examined the learning- and state-dependent dynamics of BA neurons and ventral tegmental area dopamine axons that innervate BA (VTADA→BA) using two-photon imaging and photometry in behaving mice. BA neurons did not respond to arbitrary visual stimuli, but acquired responses to stimuli that predicted either rewards or punishments. Most VTADA→BA axons were activated by both rewards and punishments, and acquired responses to cues predicting these outcomes during learning. Responses to cues predicting food rewards in VTADA→BA axons and BA neurons in hungry mice were strongly attenuated following satiation, while responses to cues predicting unavoidable punishments persisted or increased. Therefore, VTADA→BA axons may provide a reinforcement signal of motivational salience that invigorates adaptive behaviors by promoting learned responses to appetitive or aversive cues in distinct, intermingled sets of BA excitatory neurons. |
| Databáze: | OpenAIRE |
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