Visual evoked potentials findings in course of paclitaxel doxorubicin combination chemotherapy
| Autor: | Elena Palazzini, V. Scaioli, Emiliana Tarenzi, Augusto Caraceni, Cinzia Martini, Elisabetta Munzone, Fabio Fulfaro |
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| Rok vydání: | 1995 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Visual acuity Paclitaxel genetic structures medicine.medical_treatment Breast Neoplasms Optic neuropathy chemistry.chemical_compound Internal medicine Antineoplastic Combined Chemotherapy Protocols Electroretinography medicine Humans Doxorubicin Peripheral Nerves Chemotherapy business.industry Extremities Combination chemotherapy Middle Aged medicine.disease Electrophysiology Peripheral neuropathy Neurology chemistry Optic nerve Evoked Potentials Visual Female Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Journal of Neuro-Oncology. 25:221-225 |
| ISSN: | 1573-7373 0167-594X |
| Popis: | The case of a 63 year-old woman affected by advanced breast cancer is reported. Chemotherapy with paclitaxel (200 mg/m2) and doxorubicin (60 mg/m2) every three weeks was given for 8 cycles. The patient progressively developed a sensory-motor neuropathy of axonal type. After the 6th chemotherapy cycle the patient complained of subjective visual symptoms without a relevant reduction of visual acuity. Visual evoked potentials (VEPs) showed an important reduction of the amplitude of the P100 component with a less pronounced delay in latency. Electroretinic responses were normal. These findings suggest an optic neuropathy, confirming previous reports of the occurrence of optic nerve involvement in course of paclitaxel chemotherapy. The role of VEP assessment in course of paclitaxel chemotherapy is discussed comparing clinical and neurophysiological findings in this case with three previously reported cases. |
| Databáze: | OpenAIRE |
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