Role of detection of lipoarabinomannan (LAM) in urine for diagnosis of pulmonary tuberculosis in HIV patients: Egyptian experience
| Autor: | Mohamed Zaghloul, Amal Fathy, Nessrin Shalaby, Asem A. Hewidy, Heba Elshahawy, Nagwa Elhalawany, Ahmed El-Morsy |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Tuberculosis Urinary system Human immunodeficiency virus (HIV) Urine medicine.disease_cause Diseases of the respiratory system 03 medical and health sciences 0302 clinical medicine Pulmonary tuberculosis Positive predicative value Internal medicine medicine Lipoarabinomannan (LAM) 030212 general & internal medicine 0303 health sciences Lipoarabinomannan RC705-779 RC86-88.9 030306 microbiology business.industry HIV Medical emergencies. Critical care. Intensive care. First aid equipment and supplies bacterial infections and mycoses medicine.disease Hiv patients business |
| Zdroj: | The Egyptian Journal of Bronchology, Vol 15, Iss 1, Pp 1-8 (2021) |
| ISSN: | 2314-8551 1687-8426 |
| DOI: | 10.1186/s43168-021-00067-w |
| Popis: | Background Tuberculosis remains a worldwide problem fueled by the HIV epidemic. TB infection impacts HIV progression and mortality even with treatment. Egypt has increasing HIV prevalence, although still in low prevalent areas. Results Urinary LAM was positive in 22 (95.7%) of TB patients and 1 (1.9%) of non TB group. Sensitivity was 95.7%, specificity 98.1%, positive and negative predictive values were 95.7% and 98.1% respectively, with accuracy 97.4%. Urinary LAM ELISA assay has the highest sensitivity (95.7%) in relation to other tests used for TB detection in HIV patients and its concentration was highly correlated to CD4 cell count and the extent of radiological changes. Conclusion The use of urinary LAM in HIV patients is rapid, safe, available, and helpful tool for ruling in TB especially for those who cannot expectorate, critically ill, with low CD4, or presented by multiple system affection. |
| Databáze: | OpenAIRE |
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