Increased CXCL-13 levels in human African trypanosomiasis meningo-encephalitis

Autor: Théophile Josenando, Bernard Bouteille, Gedeao Vatunga, Bertrand Courtioux, Benoît Marin, Lynda Pervieux, Marie-Odile Jauberteau-Marchan, Sylvie Bisser
Přispěvatelé: Neuroépidémiologie Tropicale et Comparée (NETEC), Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Université de Limoges (UNILIM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Homéostasie Cellulaire et Pathologies (HCP), Université de Limoges (UNILIM)-CHU Limoges-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Service de Parasitologie Mycologie [CHU Limoges]
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Male
Chemokine
Trypanosoma brucei gambiense
0302 clinical medicine
Medicine
African trypanosomiasis
CXCL-13
Child
Aged
80 and over
B-Lymphocytes
biology
Meningoencephalitis
Middle Aged
3. Good health
Infectious Diseases
Encephalitis
Female
Cohort study
Adult
meningo-encephalitis
medicine.medical_specialty
Adolescent
human African trypanosomiasis
030231 tropical medicine
Central Nervous System Protozoal Infections
Enzyme-Linked Immunosorbent Assay
neurological stage
Central nervous system disease
03 medical and health sciences
Young Adult
Humans
Meningitis
Aged
business.industry
Public Health
Environmental and Occupational Health
medicine.disease
Colony-stimulating factor
Chemokine CXCL13
Surgery
Trypanosomiasis
African
Angola
BCA-1
Immunology
biology.protein
Parasitology
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
Trypanosomiasis
030217 neurology & neurosurgery
Biomarkers
Zdroj: Tropical Medicine and International Health
Tropical Medicine and International Health, Wiley-Blackwell, 2009, 14 (5), pp.529-534. ⟨10.1111/j.1365-3156.2009.02263.x⟩
ISSN: 1360-2276
1365-3156
DOI: 10.1111/j.1365-3156.2009.02263.x⟩
Popis: International audience; Summary Objectives To determine the role of the B-cell attracting chemokine CXCL-13, which may initiate B-cell trafficking and IgM production in diagnosing HAT meningo-encephalitis. Methods We determined CXCL-13 levels by ELISA on paired sera and CSF of 26 patients from Angola and of 16 controls (six endemic and ten non-endemic). Results were compared to standard stage determination markers and IgM intrathecal synthesis. Results CXCL-13 levels in patients' sera had a median value of 386.6 pg/ml and increased levels were associated with presence of trypanosomes in the CSF but not with other stage markers. CXCL-13 levels in patients' CSF had a median value of 80.9 pg/ml and increased levels were associated with all standard stage determination markers and IgM intrathecal synthesis. Conclusion CXCL-13 levels in CSF increased significantly during the course of HAT. Hence the value of CXCL-13 for diagnosis, follow-up or as a marker of disease severity should be tested in a well-defined cohort study.
Databáze: OpenAIRE
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