Inflammatory cytokines induce synthesis and secretion of gro protein and a neutrophil chemotactic factor but not beta 2-microglobulin in human synovial cells and fibroblasts
| Autor: | P Mason, P Nyirkos, E E Golds |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_treatment
Chemokine CXCL1 Molecular Sequence Data Biology Biochemistry Monocytes Proto-Oncogene Proteins medicine Humans Secretion Interleukin 8 Amino Acid Sequence Molecular Biology Lung Cells Cultured Chemotactic Factors Beta-2 microglobulin Tumor Necrosis Factor-alpha Interleukin-8 Synovial Membrane Interleukin Cell Biology Fibroblasts Molecular biology medicine.anatomical_structure Cytokine Synovial Cell Intercellular Signaling Peptides and Proteins Tumor necrosis factor alpha Synovial membrane beta 2-Microglobulin Chemokines CXC Research Article Interleukin-1 |
| Popis: | Exposure of human synovial cells and fibroblasts in monolayer culture to interleukin 1 results in prominent secretion of proteins with Mr values of 6000 and 7000. By N-terminal sequence analysis, the Mr-6000 protein is identified as the protein encoded by a recently described gro mRNA. The Mr-7000 protein is identical to a neutrophil chemotactic factor released from monocytes. Stimulation of normal human fibroblasts with tumour necrosis factor alpha also results in expression and secretion of these two proteins. In addition to these cytokine-induced proteins, we have identified beta 2-microglobulin as an Mr-8000 protein constitutively secreted by synovial cells. |
| Databáze: | OpenAIRE |
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