Baroreceptor Reflex and Integrative Stress Responses in Chronic Fatigue Syndrome
| Autor: | R Golfetti, Bushra Qureishi, John J. LaManca, Arnold Peckerman, Yoshiharu Yamamoto, Benjamin H. Natelson, Kristina A. Dahl |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Baroreceptor Posture Stress testing Hemodynamics Blood Pressure Pressoreceptors Orthostatic vital signs Heart Rate Stress Physiological Internal medicine Heart rate Chronic fatigue syndrome Humans Speech Medicine Applied Psychology Fatigue Syndrome Chronic Reflex Abnormal business.industry musculoskeletal neural and ocular physiology Baroreflex Middle Aged medicine.disease Adaptation Physiological Psychiatry and Mental health Blood pressure nervous system Cardiology Reflex Female business Stress Psychological |
| Zdroj: | Psychosomatic Medicine. 65:889-895 |
| ISSN: | 0033-3174 |
| DOI: | 10.1097/01.psy.0000079408.62277.3d |
| Popis: | Objective Altered cardiovascular responses to mental and postural stressors have been reported in chronic fatigue syndrome (CFS). This study examined whether those findings may involve changes in baroreceptor reflex functioning. Methods Chronotropic baroreceptor reflex (by sequential analysis) and cardiovascular stress responses were recorded during postural (5-minute of active standing) and cognitive (speech task) stress testing in patients with CFS grouped into cases with severe (N = 21) or less severe (N = 22) illness, and in 29 matched control subjects. Results Patients with CFS had a greater decline in baroreceptor reflex sensitivity (BRS) during standing, although only those with severe CFS were significantly different from the controls. Systolic blood pressure declined during standing in the control group but was maintained in the CFS patients. In contrast, the patients with less severe CFS had blunted increases in blood pressure during the speech task, which could not, however, be explained by inadequate inhibition of the baroreceptor reflex, with all groups showing an appropriate reduction in BRS during the task. Conclusions These results indicate that in CFS, deficiencies in orthostatic regulation, but not in centrally mediated stress responses, may involve the baroreceptor reflex. This study also suggests that classifying patients with CFS on illness severity may discriminate between patients with abnormalities in peripheral vs. central mechanisms of cardiovascular stress responses. |
| Databáze: | OpenAIRE |
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