Stimulus characterization of estradiol applying a crossfamiliarization taste aversion procedure in female mice
| Autor: | Bernard W.M.M. Peeters, Chris L.E. Broekkamp, René De Beun |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Apomorphine Ratón Conditioning Classical Experimental and Cognitive Psychology Stimulus (physiology) Lithium Discrimination Learning Behavioral Neuroscience chemistry.chemical_compound Mice Chlorides Internal medicine medicine Avoidance Learning Animals Testosterone Progesterone Dose-Response Relationship Drug Estradiol Endocrinology chemistry Taste Mental Recall Taste aversion Lithium chloride Female Lithium Chloride medicine.drug Hormone |
| Zdroj: | Physiologybehavior. 53(4) |
| ISSN: | 0031-9384 |
| Popis: | In female mice (n = 240), the estradiol stimulus was characterized by studying preexposure effects of sex steroids and sickness-inducing drugs on estradiol-induced (50 micrograms/kg SC) conditioned taste aversion (CTA). It was established that preexposure to estradiol itself (2-50 micrograms/kg SC) attenuates the development of CTA produced by the hormone. Only partial crossfamiliarization effects were found with progesterone (50-200 micrograms/kg SC) and testosterone (250-1000 micrograms/kg SC), steroids that induce CTA themselves. Preexposure to the sickness-inducing drugs lithium chloride (22 mg/kg SC) and apomorphine (0.1-0.2 mg/kg SC) prevented or substantially reduced the development of estradiol-induced CTA, respectively. It was concluded that only a low degree of stimulus resemblance exists between estradiol and the other principal sex steroids, progesterone and testosterone. In addition, it was concluded that the estradiol stimulus resembles the stimuli produced by sickness-inducing drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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