The utility of hERG channel inhibition data in the derivation of occupational exposure limits

Autor:	Jillian A. Parker, Ernest S. Fung, Alejandra Trejo-Martin, Lisa Liang, Katherine Gibbs, Suren Bandara, Stephanie Chen, Reena Sandhu, Joel Bercu, Andrew Maier
Rok vydání:	2022
Předmět:	ERG1 Potassium Channel Long QT Syndrome Occupational Exposure Potassium Channel Blockers Humans General Medicine Toxicology Ether Ether-A-Go-Go Potassium Channels
Zdroj:	Regulatory toxicology and pharmacology : RTP. 134
ISSN:	1096-0295
Popis:	Inhibition of the human ether-à-go-go (hERG) channel may lead to QT prolongation and fatal arrhythmia. While pharmaceutical drug candidates that exhibit potent hERG channel inhibition often fail early in development, many drugs with both cardiac and non-cardiac indications proceed to market. In this study, the relationship between in vitro hERG channel inhibition and published occupational exposure limit (OEL) was evaluated. A total of 23 cardiac drugs and 44 drugs with non-cardiac indications with published hERG channel IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52be179d00f4f514f91a63cd310ba0f0 https://pubmed.ncbi.nlm.nih.gov/35817210 Zobrazit plný text záznamu Full Text from ScienceDirect