Ovarian cycle-related changes of glial fibrillary acidic protein (GFAP) immunoreactivity in the rat interpeduncular nucleus
| Autor: | Eleni Michaloudi, Georgios C. Papadopoulos, Katalin Halasy, Balázs Gerics, Ferenc Hajós, Ferenc Szalay |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
endocrine system
medicine.medical_specialty Interpeduncular nucleus Ovary Biology Immunoenzyme Techniques Estrus Mesencephalon Internal medicine Glial Fibrillary Acidic Protein Limbic System medicine Animals Endocrine system Rats Wistar Gonadal Steroid Hormones Molecular Biology Glial fibrillary acidic protein urogenital system General Neuroscience GFAP stain Rats Endocrinology medicine.anatomical_structure nervous system Hypothalamus Astrocytes biology.protein Neuroglia Female Neurology (clinical) hormones hormone substitutes and hormone antagonists Developmental Biology Astrocyte |
| Zdroj: | Brain Research. 862:43-48 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(00)02065-5 |
| Popis: | The interpeduncular nucleus (IPN) of female rats was studied across the estrous cycle to observe whether the expression of the astroglial marker, glial fibrillary acidic protein (GFAP) reacts to hormonal changes in an area not belonging to the 'endocrine brain'. A marked reduction of immunoreactive GFAP was observed in estrus as compared to the immunoreactivities in met- and proestrus. This finding is consistent with earlier observations in the endocrine hypothalamus, but also proves that gonadal steroids influence astroglia in brain regions not involved in neuroendocrine regulation. Since cyclic fluctuations of synaptic numbers in the female have been described only for the endocrine hypothalamus, decrease of immunoreactive GFAP in the IPN during estrus may reflect a down-regulation of GFAP synthesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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