Antimüllerian Hormone Levels of Infants with Premature Thelarche

Autor: Elvan Bayramoğlu, Erdal Kurnaz, Hatice Nursun Özcan, Zehra Aycan, Semra Çetinkaya, Melikşah Keskin, Nursel Muratoglu Sahin, Şenay Savaş-Erdeve
Rok vydání: 2019
Předmět:
Anti-Mullerian Hormone
endocrine system
medicine.medical_specialty
endocrine system diseases
premature thelarche
Endocrinology
Diabetes and Metabolism
Puberty
Precocious
030209 endocrinology & metabolism
lcsh:Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
Follicle
0302 clinical medicine
Endocrinology
Premature thelarche
Internal medicine
Healthy control
AMH
Humans
Medicine
Prospective Studies
infancy
Patient group
Antimullerian Hormone
lcsh:RC648-665
030219 obstetrics & reproductive medicine
urogenital system
business.industry
lcsh:RJ1-570
Infant
lcsh:Pediatrics
Bone age
Prognosis
mini-puberty
Case-Control Studies
Child
Preschool
Pediatrics
Perinatology and Child Health
Female
Original Article
business
Luteinizing hormone
Biomarkers
hormones
hormone substitutes
and hormone antagonists
Follow-Up Studies
Hormone
Zdroj: JCRPE, Vol 11, Iss 3, Pp 287-292 (2019)
Journal of Clinical Research in Pediatric Endocrinology
ISSN: 1308-5735
1308-5727
DOI: 10.4274/jcrpe.galenos.2019.2018.0293
Popis: Objective Antimullerian hormone (AMH) concentrations in mini puberty are higher than those reported for the prepubertal period. In this study we investigated AMH concentrations in infants with premature thelarche (PT). A healthy control group was used for comparison. Methods Forty five female infants with PT, aged between one and three years and a control group consisting of 37 healthy girls in the same age range were included in the study. Bone age, pelvic ultrasonography, and concentrations of luteinizing hormone, follicle-stimulating hormone (FSH), estradiol and AMH of the patient group were evaluated. Only serum AMH concentration of the control group was evaluated. Results Median (range) serum AMH concentrations in the subjects were 1.66 ng/mL (11.85 pmol/L) [0.15-6.32 ng/mL (1.07-45.12 pmol/L)] and were significantly lower (p=0.025) than for the control group; 1.96 ng/mL (13.99 pmol/L) [0.60-8.49 ng/mL (4.28-60.64 pmol/L)]. AMH and FSH were negatively correlated (r=-0.360, p=0.015) in infants with PT. There was no correlation between AMH and uterine size, uterine volume, endometrial thickness, fundocervical ratio, ovarian size or volume, follicle size and follicle number. Conclusion This is the first study that investigates AMH concentrations in infants with PT. The low AMH levels in these infants and the negative correlation between AMH and FSH suggests that AMH may play a role in suppressing pubertal findings during infancy and that decreased AMH may cause PT in infancy.
Databáze: OpenAIRE
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