INFLUENCE OF THE COMPOUND SS-68 ON THE ELECTROPHYSIOLOGICAL EFFECTS OF ADRENOMIMETICS IN RAT RIGHT ATRIUM

Autor:	A. V. Zelenskaya, D. V. Abramochkin, S. K. Bogus, K. F. Suzdalev, P. A. Galenko-Yaroshevsky
Jazyk:	ruština
Rok vydání:	2017
Předmět:	medicine.medical_specialty adrenoreceptors Adrenergic receptor Chemistry isoproterenol Stimulation heart Pharmacology Atenolol Methoxamine compound ss-68 Electrophysiology Endocrinology Rhythm action potential Internal medicine medicine Medicine Sinus rhythm methoxamine IC50 medicine.drug
Zdroj:	Кубанский научный медицинский вестник, Vol 1, Iss 2, Pp 24-29 (2017)
ISSN:	2541-9544 1608-6228
Popis:	The influence of compound SS-68, known for its marked antiarrhythmic properties, on the intension of electrophysiological effects of α1- и β- adrenoreceptors stimulation was studied in right atrial preparations from rat. Activation of α1-adrenoreceptors by methoxamine (3×10-5М) led to prominent prolongation of action potentials without significant changes in their rhythm. SS-68 attenuated this effect with IC50 = 5,27×10-6М. The standard α1-blocker prazosine appeared to be more effective (IC50 = 2×10-7М). The activation of β-adrenoreceptors by isoproterenol (3×10-7М) led to drastic acceleration of sinus rhythm. However, only the highest tested concentration of SS-68 (3×10-5М) reduced this effect, while the conventional β-blocker atenolol effectively inhibited it with IC50 = 3,95×10-6М.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b92529082c414d44f57c8c03f4aaf1 https://ksma.elpub.ru/jour/article/view/696 Zobrazit plný text záznamu