Using Extinction-Renewal to Circumvent the Memory Strength Boundary Condition in Fear Memory Reconsolidation
| Autor: | Mitch A McDaniel, Mallory E Dunn, Tiffany L. Campbell, Mallory K Myers, Victoria A Diana, Daniel E. Kochli, Jennifer J. Quinn |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Fear memory
genetic structures Context (language use) Neurosciences. Biological psychiatry. Neuropsychiatry Article 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine destabilization medicine 0501 psychology and cognitive sciences rat learning business.industry Overtraining General Neuroscience 05 social sciences Extinction (psychology) medicine.disease Tone (literature) Single tone overtraining midazolam Midazolam Memory consolidation business Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes medicine.drug RC321-571 |
| Zdroj: | Brain Sciences, Vol 11, Iss 1023, p 1023 (2021) Brain Sciences Volume 11 Issue 8 |
| ISSN: | 2076-3425 |
| Popis: | Reconsolidation is a process by which memories are destabilized, updated, and then restabilized. Strong memories are resistant to undergoing reconsolidation. Here, we addressed whether an overtrained fear memory could be made susceptible to reconsolidation by first extinguishing, and then renewing, the memory. Rats were trained with ten tone-footshock pairings, followed by eight days of tone extinction in the training context. The next day, rats were placed into a second context and memory for the tone was renewed/reactivated with a single tone presentation. Immediately following reactivation, rats received an injection of midazolam or vehicle. Rats were then tested for freezing to the tone in a third context. Midazolam had no effect in rats that did not undergo tone extinction, but significantly attenuated freezing to the tone in extinguished rats. Thus, rats that received tone extinction underwent tone memory reconsolidation following its renewal. In a second experiment, we administered the reactivation session and midazolam injections prior to extinction. Midazolam had no effect and rats extinguished at a rate similar to controls. These data suggest that strong emotional memories are capable of updating following weakening of memory expression through extinction. |
| Databáze: | OpenAIRE |
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