LIGHT/TNFSF14 enhances adipose tissue inflammatory responses through its interaction with HVEM
| Autor: | Teruo Kawada, Choon-Soo Jeong, Hong-Min Kim, Hye-Sun Choi, Rina Yu |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Tumor Necrosis Factor Ligand Superfamily Member 14
medicine.medical_specialty Macrophage Adipose Tissue White medicine.medical_treatment Adipose tissue macrophages Biophysics Adipose tissue Inflammation Biology Biochemistry Cell Line Mice Downregulation and upregulation Structural Biology Internal medicine Adipocytes Genetics medicine Animals Obesity RNA Messenger Receptor Cytokine Molecular Biology Cells Cultured Mice Knockout Chemotaxis Macrophages Cell Biology Dietary Fats Mice Inbred C57BL Oxidative Stress Endocrinology Gene Expression Regulation Culture Media Conditioned Cytokines Inflammation Mediators Stromal Cells medicine.symptom Receptors Tumor Necrosis Factor Member 14 |
| Zdroj: | FEBS Letters. 585:579-584 |
| ISSN: | 0014-5793 |
| Popis: | Obesity-induced adipose tissue inflammation is characterized by increased macrophage infiltration and cytokine production, and is associated with metabolic disorders. LIGHT/TNFSF14, a member of the TNF superfamily, plays a role in the development of various inflammatory diseases. The purpose of this study was to examine the involvement of soluble LIGHT (sLIGHT) in obesity-induced adipose tissue inflammatory responses. LIGHT gene expression on macrophages/adipocytes was upregulated by treatment with obesity-related factors. sLIGHT displayed chemotactic activity for macrophages and T cells, and enhanced inflammatory cytokine release from macrophages, adipocytes, and adipose tissue-derived SVF cells. The sLIGHT-induced inflammatory responses were blunted by neutralizing anti-HVEM antibody or knockout of HVEM, a receptor for sLIGHT. These findings indicate that sLIGHT enhances adipose tissue inflammatory responses through its interaction with HVEM. |
| Databáze: | OpenAIRE |
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