Selective approach to radionuclide-guided sentinel lymph node biopsy in high-risk ductal carcinoma in situ of the breast
| Autor: | Farida al Kandari, Fawaz Abu al Huda, Haider Ali Khan, Sharjeel Usmani, Naheel al Nafisi, Fahad Marafi, Noha Al Saleh, Henney G. Amanguno |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Axillary lymph nodes Sentinel lymph node Breast Neoplasms Scintigraphy Metastasis Biopsy medicine Humans Radiology Nuclear Medicine and imaging Neoplasm Invasiveness skin and connective tissue diseases Lymph node Technetium Tc 99m Aggregated Albumin Aged medicine.diagnostic_test business.industry Sentinel Lymph Node Biopsy General Medicine Ductal carcinoma Middle Aged medicine.disease Axilla medicine.anatomical_structure Carcinoma Intraductal Noninfiltrating Lymphatic Metastasis Female Radiology Lymph Nodes Radiopharmaceuticals business Lymphoscintigraphy |
| Zdroj: | Nuclear medicine communications. 32(11) |
| ISSN: | 1473-5628 |
| Popis: | PURPOSE Ductal carcinoma in situ (DCIS) currently represents approximately 15-25% of all breast cancers detected. Although inherently a noninvasive disease, occult invasive disease can be found at definitive histology. The role of sentinel lymph node (SLN) biopsy in DCIS is still unclear. The aim of this study was to evaluate the clinical usefulness of SLN biopsy and the incidence of SLN metastases in selected patients with high-risk DCIS, who are at highest risk for being upstaged to invasive carcinoma. MATERIALS AND METHODS Twenty-three high-risk patients with DCIS proven on core biopsy (mean age, 50 years; median age, 48 years; age range, 37-78 years) were included in the study. SLN scintigraphy was performed 2-4 h before surgery by injecting Tc-99m-labeled nanocolloid intradermally in the periareolar region. The first lymph node to appear on the scan was labeled as SLN and was marked on the skin by using a γ probe. The lymph node was explored in the axilla using a γ probe. RESULTS The SLN was identified in all patients (100% success rate). Of 23 cases of DCIS on core biopsy, seven patients (30%) were shown to have invasive ductal carcinoma on final histological specimen. Among these seven patients, three had minimal invasive carcinoma ( |
| Databáze: | OpenAIRE |
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