Role of topical oxytocin in improving vaginal atrophy in postmenopausal women: a randomized, controlled trial
| Autor: | A Taha, S Zaki, T Fares, Asem Moussa, Heba Marie, A Abo-Louz, El-Sayed El-Desouky, Haitham Torky, Ahmed N. Eesa, A M Ahmad, Osama Kamal Raslan |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Vaginal Diseases Placebo Oxytocin Placebo group Epithelium law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Oxytocics Medicine Humans Single-Blind Method 030212 general & internal medicine Prospective Studies 030219 obstetrics & reproductive medicine Postmenopausal women Estradiol business.industry Significant difference Obstetrics and Gynecology General Medicine Middle Aged medicine.disease Postmenopause Administration Intravaginal Dyspareunia Inclusion and exclusion criteria Vagina Egypt Female Vaginal atrophy Atrophy business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Climacteric : the journal of the International Menopause Society. 21(2) |
| ISSN: | 1473-0804 |
| Popis: | Prospective randomized controlled trial to test the effectiveness of topical oxytocin gel to improve vaginal atrophy in postmenopausal women.A total of 140 postmenopausal women presenting with vaginal atrophy and who satisfied the inclusion and exclusion criteria were randomized into two groups each of 70 patients; they received intravaginal oxytocin gel or placebo gel for 30 days. Serum estrogen level, visual, colposcopic and histological vaginal examination were performed before and after treatment.Forty-seven out of 70 women in the oxytocin gel group improved after treatment and none in the placebo group (p = 0.001). Forty-five participants in the oxytocin group and seven in the placebo group reported relief of dyspareunia (p = 0.001). Thirty-four participants in the oxytocin group and seven in the placebo group reported relief of soreness (p = 0.001). There was no significant difference between the circulating levels of estradiol in both groups before and after treatment (p = 0.4 and 0.6 for the oxytocin group and the placebo group, respectively).Oxytocin gel is useful in the restoration of the vaginal epithelium in cases of postmenopausal atrophic vaginitis. Further studies with a longer follow-up period are required to test the long-term effects of oxytocin as a treatment for vaginal atrophy. |
| Databáze: | OpenAIRE |
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