MicroRNAs alteration as early biomarkers for cancer and neurodegenerative diseases: New challenges in pesticides exposure
| Autor: | Michele Teodoro, Giusi Briguglio, Carmela Alessandra Rugolo, Federica Giambò, Concettina Fenga, Carmela Alibrando, Chiara Costa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Health
Toxicology and Mutagenesis Disease 010501 environmental sciences Biology Toxicology Bioinformatics 01 natural sciences Metastasis Biological pathway 03 medical and health sciences 0302 clinical medicine Mirna expression lcsh:RA1190-1270 microRNA medicine Cancer miRNA Neurodegenerative diseases Pesticides 0105 earth and related environmental sciences lcsh:Toxicology. Poisons ComputingMethodologies_COMPUTERGRAPHICS Cell growth Regular Article medicine.disease Biomarker (medicine) 030217 neurology & neurosurgery |
| Zdroj: | Toxicology Reports Toxicology Reports, Vol 7, Iss, Pp 759-767 (2020) |
| ISSN: | 2214-7500 |
| Popis: | Graphical abstract Highlights • Current knowledge linking pesticide exposure, cancer and neuro-degenerative diseases to dysregulation of microRNA network was summarized. • Literature indicates differential miRNA expression targeting biomolecules and pathways involved in cancer and neurodegenerative diseases. • Evaluation of miRNA expression may be used to develop new non-invasive strategies for the prediction and prognosis of diseases including cancer. • The application of miRNAs as diagnostic and therapeutic biomarkers in the clinical field is extremely challenging. This review summarizes the current knowledge linking cancer and neuro-degenerative diseases to dysregulation of microRNA network following pesticide exposure. Most findings revealed differential miRNA expression targeting biomolecules and pathways involved in various neoplastic localizations and neurodegenerative diseases. A growing body of evidence in recent literature indicates that alteration of specific miRNAs can represent an early biomarker of disease following exposure to chemical agents, including pesticides. Different miRNAs seem to regulate cell proliferation, apoptosis, migration, invasion, and metastasis via many biological pathways through modulation of the expression of target mRNAs. The evaluation of miRNA expression levels may be used to develop new non-invasive strategies for the prediction and prognosis of many diseases, including cancer. However, the application of miRNAs as diagnostic and therapeutic biomarkers in the clinical field is extremely challenging. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|