A small animal model study of perlite and fir bark dust on Guinea pig lungs
| Autor: | Joseph R. DiPalma, Robert McMichael, Peter S. Amenta, Allan P. Freedman, Robert Blumenstein, Edward J. Barbieri |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Inflammatory response Guinea Pigs Drinking Pulmonary disease complex mixtures Guinea pig Eating Small animal Aluminum Oxide Animals Lung Pharmacology Chemistry Model study Body Weight Dust Silicon Dioxide Wood respiratory tract diseases Disease Models Animal Horticulture visual_art Perlite visual_art.visual_art_medium Female Bark Nuisance |
| Zdroj: | Journal of Pharmacological Methods. 9:209-217 |
| ISSN: | 0160-5402 |
| DOI: | 10.1016/0160-5402(83)90040-2 |
| Popis: | Fir bark (Abies) and perlite (noncrystalline silicate) dusts have been reported to cause pulmonary disease in humans. Guinea pigs were exposed to either fir bark or perlite dust in a special chamber. Severe pathologic changes occurred in the lungs, consisting of lymphoid aggregated and a perivascular inflammatory response. Both dusts caused similar changes although one was vegetable (fir bark) and the other mineral (perlite). Fir bark and perlite dust appeared to be more than just nuisance dusts. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|