Role of cytokines and chemokines in non-alcoholic fatty liver disease
| Autor: | François Mach, Vincent Braunersreuther, Fabrizio Montecucco, Giorgio Luciano Viviani |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Chemokine
medicine.medical_treatment Inflammation Disease Fatty Liver/immunology/pathology/physiopathology 03 medical and health sciences 0302 clinical medicine Cytokines/immunology Fibrosis Non-alcoholic Fatty Liver Disease medicine Animals Humans 030304 developmental biology ddc:616 0303 health sciences biology business.industry Chemokines/immunology Fatty liver Gastroenterology nutritional and metabolic diseases General Medicine medicine.disease Pathophysiology digestive system diseases 3. Good health Fatty Liver Editorial Cytokine Immunology biology.protein Cytokines 030211 gastroenterology & hepatology Chemokines Steatohepatitis medicine.symptom business |
| Zdroj: | World journal of gastroenterology : WJG ResearcherID World Journal of Gastroenterology, Vol. 18, No 8 (2012) pp. 727-735 World Journal of Gastroenterology World Journal of Gastroenterology; Vol 18 |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v18.i8.727 |
| Popis: | Non-alcoholic fatty liver disease (NAFLD) includes a variety of histological conditions (ranging from liver steatosis and steatohepatitis, to fibrosis and hepatocarcinoma) that are characterized by an increased fat content within the liver. The accumulation/deposition of fat within the liver is essential for diagnosis of NAFLD and might be associated with alterations in the hepatic and systemic inflammatory state. Although it is still unclear if each histological entity represents a different disease or rather steps of the same disease, inflammatory processes in NAFLD might influence its pathophysiology and prognosis. In particular, non-alcoholic steatohepatitis (the most inflamed condition in NAFLDs, which more frequently evolves towards chronic and serious liver diseases) is characterized by a marked activation of inflammatory cells and the upregulation of several soluble inflammatory mediators. Among several mediators, cytokines and chemokines might play a pivotal active role in NAFLD and are considered as potential therapeutic targets. In this review, we will update evidence from both basic research and clinical studies on the potential role of cytokines and chemokines in the pathophysiology of NAFLD. |
| Databáze: | OpenAIRE |
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