Spatial-temporal mapping and risk factors for hand foot and mouth disease in northwestern inland China

Autor: Zhenguo Gao, Zhen-Wei Li, Jia-Te Wei, Wu-Chun Cao, Muti Mahe, Ruifang Huang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
Viral Diseases
Epidemiology
RC955-962
Social Sciences
Hand-foot-and-mouth disease
law.invention
Geographical Locations
Medical Conditions
0302 clinical medicine
law
Arctic medicine. Tropical medicine
Medicine and Health Sciences
030212 general & internal medicine
Child
Geographic Areas
Geography
Foot-and-mouth disease
Incidence (epidemiology)
Infectious Diseases
Transmission (mechanics)
Child
Preschool
Population Surveillance
Female
Public aspects of medicine
RA1-1270
Research Article
Urban Areas
China
medicine.medical_specialty
Asia
Adolescent
Human Geography
Infectious Disease Epidemiology
Urban Geography
03 medical and health sciences
Population Metrics
stomatognathic system
medicine
Humans
Population Density
Population Biology
business.industry
Infant
Newborn
Public Health
Environmental and Occupational Health
Infant
Biology and Life Sciences
medicine.disease
030104 developmental biology
Medical Risk Factors
Relative risk
People and Places
Earth Sciences
Hand
Foot and Mouth Disease
Monthly average
business
Demography
Zdroj: PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009210 (2021)
PLoS Neglected Tropical Diseases
ISSN: 1935-2735
1935-2727
Popis: Background Hand foot and mouth disease (HFMD) is becoming one of the common human infectious diseases in China. Previous studies have described HFMD in tropical or coastal areas of Asia-Pacific countries. However, limited studies have thoroughly studied the epidemiology and potential risk factors for HFMD in inland areas with complex environmental conditions. Methodology/Principal findings Using the data from 2009 to 2018 on reported cases of Xinjiang Uighur Autonomous Region, we characterized the epidemic features of HFMD. Panel negative binomial model was used to identify climate, geographical and demographic determinants for HFMD incidence. A total of 70856 HFMD cases (average annual incidence: 305 per million persons) were reported in Xinjiang during the 10-year study period, of which 10393 (14.7%) were laboratory-confirmed and 98 (0.1%) were severe. HFMD peaked in summer every year during the study period, and incidence in 2012, 2015, 2016 and 2018 had minor peaks in autumn. After adjusting the school or holiday month, multiple factors were found to affect HFMD epidemiology: urban area being major land cover type (incidence risk ratio, IRR 2.08; 95% CI 1.50, 2.89), higher gross domestic product per capita (IRR 1.14; 95% CI 1.11, 1.16), rise in monthly average temperature (IRR 1.65; 95% CI 1.61, 1.69) and monthly accumulative precipitation (IRR 1.20; 95% CI 1.16, 1.24) predicted increase in the incidence of HFMD; farmland being major land cover type (IRR 0.72; 95% CI 0.64, 0.81), an increase of percentage of the minority (IRR 0.91; 95% CI 0.89, 0.93) and population density (IRR 0.98; 95% CI 0.98, 0.99) were related to a decrease in the incidence of HFMD. Conclusions/Significance In conclusion, the epidemic status of HFMD in Xinjiang is characterized by low morbidity and fatality. Multiple factors have significant influences on the occurrence and transmission of HFMD in Xinjiang.
Author summary Hand foot and mouth disease (HFMD) is one of the common human infectious disease threating Asia-Pacific countries. To explore the epidemiology and environmental risk factors for HFMD in inland China, we utilized 10-year HFMD surveillance data in Xinjiang Uighur Autonomous Region and combined multiple spatial-temporal statistical analyses. We identified spatial-temporal clusters of HFMD incidence and found that multiple factors could affect HFMD incidence: urban area being major land cover type, higher gross domestic product per capita, rise in monthly average temperature and monthly accumulative precipitation predicted increase in the incidence of HFMD; farmland being major land cover type, an increase of percentage of the minority and population density were related to a decrease in the incidence of HFMD. Our findings facilitate the understanding of HFMD epidemiology and risk factors in different geographic regions, which are crucial for conducting prevention and control strategies of HFMD.
Databáze: OpenAIRE
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