In Vitro and in Vivo Anti-Diabetic Effects of Anthocyanins from Maqui Berry (Aristotelia chilensis)
| Autor: | Ilya Raskin, Leonel E. Rojo, David M. Ribnicky, Alexander Poulev, Mary Ann Lila, Mary H. Grace, Patricio Rojas-Silva, Peter Kuhn, Ruth Dorn, Sithes Logendra |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
biology Chemistry Insulin medicine.medical_treatment Glucose uptake General Medicine Carbohydrate metabolism biology.organism_classification medicine.disease Article Analytical Chemistry chemistry.chemical_compound Aristotelia chilensis Endocrinology Downregulation and upregulation Oral administration Internal medicine medicine Metabolic syndrome Delphinidin Food Science |
| Popis: | We used a murine model of type II diabetes, which reproduces the major features of the human disease, and a number of cellular models to study the antidiabetic effect of ANC, a standardised anthocyanin-rich formulation from maqui berry (Aristotelia chilensis). We also isolated delphinidin 3-sambubioside-5-glucoside (D3S5G), a characteristic anthocyanin from maqui berry, and studied its antidiabetic properties. We observed that oral administration of ANC improved fasting blood glucose levels and glucose tolerance in hyperglycaemic obese C57BL/6J mice fed a high fat diet. In H4IIE rat liver cells, ANC decreased glucose production and enhanced the insulin-stimulated down regulation of the gluconeogenic enzyme, glucose-6-phosphatase. In L6 myotubes ANC treatment increased both insulin and non-insulin mediated glucose uptake. As with the ACN, oral administration of pure D3S5G dose-dependently decreased fasting blood glucose levels in obese C57BL/6J mice, and decreased glucose production in rat liver cells. D3S5G also increased glucose uptake in L6 myotubes and is at least partially responsible for ANC's anti-diabetic properties. |
| Databáze: | OpenAIRE |
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