Hypocalcemia in a Patient With Osteosarcoma and 22q11.2 Deletion Syndrome
| Autor: | Jason E. Levine, Francis Mussai, Lea C. Cunningham, Lee J. Helman, James C. Reynolds, Su Young Kim, Diane C. Arthur, Robert M. Henshaw, Geoffrey Rezvani, Constantine A. Stratakis, Galina Nesterova |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
musculoskeletal diseases
Male medicine.medical_specialty Pathology Adolescent medicine.medical_treatment chemistry.chemical_element Bone Neoplasms Calcium Asymptomatic Gastroenterology Article Amputation Surgical Absorptiometry Photon Internal medicine DiGeorge syndrome medicine DiGeorge Syndrome Humans Humerus In Situ Hybridization Osteosarcoma Hypocalcemia business.industry Hematology medicine.disease medicine.anatomical_structure Oncology chemistry Amputation Pediatrics Perinatology and Child Health Etiology medicine.symptom business Complication |
| Popis: | Hypocalcemia is a rare complication of osteosarcoma, having been described in only 4 reports. We present the case of a 16-year-old male with metastatic osteosarcoma of the right humerus who was found to have severe asymptomatic hypocalcemia. Cytogenetic analysis of peripheral blood revealed a microdeletion in band 22q11.2. Following amputation of the tumor-bearing extremity, the patient's calcium levels increased, but did not normalize. These findings suggested that the etiology of his hypocalcemia was osteoblastic utilization of calcium by the tumor, exacerbated by 22q11.2 deletion syndrome. |
| Databáze: | OpenAIRE |
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