Lack of association of MRI determined subclinical cardiovascular disease with dizziness and vertigo in a cross-sectional population-based study

Autor: Anina Schafnitzel, Wieland H. Sommer, Andreas Schindler, Christa Meisinger, Eva Grill, Annette Peters, Wolfgang Rathmann, Hannah Patscheider, Ralf Strobl, Fabian Bamberg, Katharina Müller-Peltzer, Roberto Lorbeer, Margit Heier, Holger Hetterich
Rok vydání: 2016
Předmět:
Male
Central Nervous System
Cross-sectional study
lcsh:Medicine
Otology
Cardiovascular Medicine
Vascular Medicine
Biochemistry
Nervous System
Diagnostic Radiology
Orthostatic vital signs
0302 clinical medicine
Endocrinology
Glucose Metabolism
Risk Factors
Vertigo
Germany
Prevalence
Medicine and Health Sciences
Ventricular Function
030212 general & internal medicine
Prediabetes
lcsh:Science
Subclinical infection
education.field_of_study
Brain Diseases
Multidisciplinary
biology
Radiology and Imaging
Arteries
Middle Aged
Cardiovascular diseases
Central nervous system
Glucose metabolism
Diabetes mellitus
Stroke
Carotid arteries
Magnetic resonance imaging
Magnetic Resonance Imaging
Carotid Arteries
Neurology
Cardiovascular Diseases
Carbohydrate Metabolism
Female
Anatomy
Research Article
Adult
medicine.medical_specialty
Imaging Techniques
Endocrine Disorders
Cerebrovascular Diseases
Population
Research and Analysis Methods
Dizziness
03 medical and health sciences
Diagnostic Medicine
Internal medicine
medicine
Diabetes Mellitus
Humans
ddc:610
education
Aged
business.industry
lcsh:R
Biology and Life Sciences
Odds ratio
biology.organism_classification
medicine.disease
Hyperintensity
Cross-Sectional Studies
Logistic Models
Metabolism
Otorhinolaryngology
Metabolic Disorders
Physical therapy
Cardiovascular Anatomy
Blood Vessels
lcsh:Q
business
030217 neurology & neurosurgery
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 9, p e0184858 (2017)
PLoS ONE 12:e0184858 (2017)
PLOS ONE, 12(9):e0184858
ISSN: 1932-6203
Popis: OBJECTIVE: We investigated the association between subclinical cardiovascular diseases assessed by MRI examination and symptoms of dizziness and vertigo in participants of a population-based sample. METHODS: Data from 400 participants (169 women) aged from 39 to 73 of a cross-sectional MRI sub-study of the "Kooperative Gesundheitsforschung in der Region Augsburg" (KORA) FF4 study from the south of Germany was used. MRI determined subclinical cardiovascular diseases include left and right ventricular structure and function as well as the presence of carotid plaque and carotid wall thickness. Cerebrum diseases include white matter lesions (WML) and cerebral microbleeds (CMB). The main outcomes of dizziness and vertigo were assessed by standardized interview. Logistic regression models were applied and adjusted odds ratios (OR) with 95% confidence intervals (CI) were provided. RESULTS: Lifetime and 12-month prevalence of dizziness and vertigo were 30% (95%CI 26% to 35%) and 21% (95%CI 17% to 26%) respectively in this sample. On multivariable analysis, cardiac and carotid measurements were not associated with dizziness and vertigo excluding orthostatic vertigo (20%, 95CI 16% to 24%). Only in male participants, there was a significant association between WML and the presence of dizziness and vertigo (OR = 2.95, 95%CI 1.08 to 8.07). There was no significant association of CMB with dizziness and vertigo. However, CMB and WML were tending to associate with a higher risk of dizziness and vertigo in the whole sample (CMB: OR = 1.48, 95%CI 0.70; 3.15; WML: OR = 1.71, 95%CI 0.80 to 3.67;), in persons with prediabetes and diabetes (WML: OR = 2.71, 95%CI 0.89 to 8.23) and in men with normal glucose metabolism (CMB: OR = 2.60, 95%CI 0.56 to 12.0; WML: OR = 3.08, 95%CI 0.58 to 16.5). CONCLUSIONS: In this sample of participants without manifest cardiovascular diseases, subclinical left and right ventricular function and carotid structure were consistently not associated with dizziness and vertigo. Subclinical cerebrum measurements, however, tend to increase the risk for dizziness and vertigo, especially in men and in persons with prediabetes or diabetes.
Databáze: OpenAIRE
Externí odkaz: