Hypercalcemia in hyperthyroidism role of age and goiter type
| Autor: | F Ritzl, Z S Szabó |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Goiter endocrine system diseases chemistry.chemical_element Thyroid Function Tests Calcium Hyperthyroidism Thyroid function tests TRH stimulation test Internal medicine Drug Discovery Humans Medicine Genetics (clinical) Aged Calcium metabolism medicine.diagnostic_test business.industry Thyroid Age Factors Organ Size General Medicine Middle Aged medicine.disease Endocrinology medicine.anatomical_structure chemistry Calcitonin Hypercalcemia Molecular Medicine Female Thyroid function business hormones hormone substitutes and hormone antagonists Goiter Nodular |
| Zdroj: | Klinische Wochenschrift. 59:275-279 |
| ISSN: | 1432-1440 0023-2173 |
| DOI: | 10.1007/bf01478206 |
| Popis: | Hyperthyroidism is often associated with hypercalcemia which is provoked by osteoclastic activity of the thyroid hormones. These data show that hypercalcemia develops with increasing age and in the presence of a special type of hyperthyroid goiter. Total serum calcium, total protein, and albumin as well as different parameters of thyroid function, namely T3 RIA1, T4 test, ETR and TRH test were determined in a group of 147 patients. The ionized calcium level was estimated from total calcium and albumin. 211 measurements were performed. Hyperthyroidism existed in 92 cases. Total calcium was not significantly elevated in hyperthyroidism. Hyperthyroid patients under 61 years of age showed elevated ionized calcium levels in only 2.3% and patients over 60 years of age in 18.8% of cases. Elevated ionized serum calcium levels were observed in 43.8% of hyperthyroid patients with multinodular goiters. The linear correlation between ionized calcium levels and different parameters of thyroid function is much more pronounced in the older group and it was found to be highly significant. 7 of 9 hyperthyroid patients with elevated ionized calcium levels showed multinodular goiters, though no autonomous adenoma. In the hyperthyroid group of patients of over 60 years of age with multinodular goiters the incidence of hypercalcemia was 43.8%. Direct action of thyroid hormone on calcium turnover as well as increasing age and special goiter type seem to be responsible for disturbances in calcium metabolism. A possible calcitonin deficiency in the above mentioned conditions is discussed. |
| Databáze: | OpenAIRE |
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