Intravenous lidocaine versus intravenous amiodarone (in a new aqueous formulation) for incessant ventricular tachycardia
| Autor: | Walter P Paladino, Janos Molnar, Duane E. Bridges, Nicholas Z. Kerin, Charles I. Haffajee, Sandor Timar, John C. Somberg, Steven J. Bailin |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Lidocaine Heart disease medicine.medical_treatment Electric Countershock Amiodarone Blood Pressure Antiarrhythmic agent Ventricular tachycardia Electrocardiography Double-Blind Method Internal medicine medicine Humans Treatment Failure Infusions Intravenous Aged Aged 80 and over Chemotherapy business.industry Intravenous amiodarone Middle Aged medicine.disease Anesthesia Shock (circulatory) Tachycardia Ventricular Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents medicine.drug |
| Zdroj: | The American Journal of Cardiology. 90:853-859 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/s0002-9149(02)02707-8 |
| Popis: | The effectiveness of intravenous amiodarone for the treatment of incessant (shock resistant) ventricular tachycardia (VT) has not been established. This study evaluated the efficacy of a water-soluble amiodarone preparation or lidocaine for the treatment of shock-resistant VT. The trial was a double-blinded parallel design. Patients were randomized to receive up to 2 boluses of either 150 mg intravenous amiodarone or 2 boluses of 100 mg lidocaine followed by a 24-hour infusion. If the first assigned medication failed to terminate VT, the patient was crossed over to the alternative therapy. Twenty-nine patients were randomized to the study (18 received amiodarone and 11 received lidocaine). There were no significant differences between groups with regard to baseline characteristics. Immediate VT termination was achieved in 14 patients (78%) with amiodarone versus 3 patients (27%) on lidocaine (p |
| Databáze: | OpenAIRE |
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