Monolithic Silica Support for Immobilized Catalysis in Continuous Flow
| Autor: | Rachel L. Beingessner, J. F. Hunter, M. Grace Russell, Timothy F. Jamison, Cedrick Veryser |
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| Přispěvatelé: | Massachusetts Institute of Technology. Department of Chemistry, Massachusetts Institute of Technology. Department of Materials Science and Engineering |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Prof. Jamison |
| Popis: | Monolithic and packed‐bed reactors featuring immobilized catalysts are well‐precedented in continuous flow synthesis but can suffer from adverse pressure drops during use due to their small pore sizes and/or structural changes. Herein, we overcome this challenge with the synthesis of a structurally robust silica‐based monolith featuring pore sizes on the millimeter scale. The 3‐dimensional solid support structure is constructed from a polystyrene foam‐based template and features a functional group handle that can be modified to display a reactive catalyst. Here we functionalize the support with palladium(0) for hydrogenation reactions and a modified proline catalyst for the alpha functionalization of aldehydes. Both reactors showed good activity and excellent catalytic longevity when utilized under continuous flow conditions. DARPA (Contract ARO W911NF-16-2-0023) |
| Databáze: | OpenAIRE |
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